Fibronectin Solution (LIF) Mouse Recombinant Protein

FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: ER-Golgi intermediate compartment; extracellular matrix; extracellular region; extracellular space; fibrinogen complex; proteinaceous extracellular matrix

Molecular Function: identical protein binding; integrin binding; protease binding; protein binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; integrin activation; leukocyte migration; peptide cross-linking; platelet degranulation; positive regulation of cell proliferation; positive regulation of fibroblast proliferation; regulation of protein amino acid phosphorylation

Disease: Glomerulopathy With Fibronectin Deposits 2; Plasma Fibronectin Deficiency