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Pigment Epithelium-Derived Factor (PEDF) (ProNGF) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555641

ProNGF is the pro-form of the neurotrophin nerve growth factor. Like the mature protein proNGF is characterized by the cysteine knot motif consisting of three cysteine bridges. The protein predominantly exists as a non-covalently linked homodimer. More details

$240 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pigment Epithelium-Derived Factor (PEDF) (ProNGF), Recombinant Protein
Full Product Name
Pigment Epithelium-Derived Factor (PEDF), Recombinant Protein
Product Gene Name
ProNGF recombinant protein
Species Reactivity
Human
Preparation and Storage
Store at 4-8 degrees
Molecular Weight
46,312 Da
OMIM
172860
Technical Note
The proNGF is a 50 kDa dimer in solution, on SDS-PAGE monomer at about 25-30 kDa is detected. To analyze this protein on an SDS-PAGE., DTT as a reduction agent is absolutely necessary.

Product Categories/Family for ProNGF recombinant protein

ProNGF

Testing Data of ProNGF recombinant protein

Image: SDS-Page of proNGF
Human ProNGF Recombinant Protein – Cat# MBS555641

Testing Data of ProNGF recombinant protein

Image: SDS-Page of proNGF
Human ProNGF Recombinant Protein, Testing Data – Cat# MBS555641

Other Notes

Small volumes of ProNGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ProNGF purchase

MBS555641 is a recombinant protein targeting ProNGF. Also known as Pigment Epithelium-Derived Factor (PEDF), Recombinant Protein. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for ProNGF. It may not necessarily be applicable to this product.

NCBI GI #
39725934
NCBI GeneID
5176
NCBI Accession #
NP_002606.3
UniProt Secondary Accession #
Q13236; Q2TU83; Q96CT1; Q96R01; Q9BWA4; F1T092
UniProt Related Accession #
P36955
GenBank Nucleotide #
NM_002615.5
NCBI Official Full Name
pigment epithelium-derived factor
NCBI Official Synonym Full Names
serpin family F member 1
NCBI Official Symbol
SERPINF1
NCBI Official Synonym Symbols
OI6; OI12; PEDF; EPC-1; PIG35
UniProt Protein Name
Pigment epithelium-derived factor
UniProt Synonym Protein Names
Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1
Protein Family
Pigment epithelium-derived factor
UniProt Gene Name
SERPINF1
UniProt Synonym Gene Names
PEDF; PEDF
UniProt Entry Name
PEDF_HUMAN
NCBI Protein Information
pigment epithelium-derived factor

UniProt Comments for ProNGF

PEDF: a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: extracellular matrix; extracellular region; extracellular space

Molecular Function: protein binding; serine-type endopeptidase inhibitor activity

Biological Process: cell proliferation; multicellular organismal development; negative regulation of angiogenesis; positive regulation of neurogenesis

Disease: Osteogenesis Imperfecta, Type Vi
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ProNGF recombinant protein

 Products by Pathway  Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram

Diseases associated with ProNGF recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with ProNGF and Disease Models, Animal
 Atrophy Antibodies  >1 publications with ProNGF and Atrophy
 Nerve Degeneration Antibodies  >1 publications with ProNGF and Nerve Degeneration
 Proteinuria Antibodies  >1 publications with ProNGF and Proteinuria
 Cell Transformation, Neoplastic Antibodies  >1 publications with ProNGF and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >1 publications with ProNGF and Lung Neoplasms
 Kidney Diseases Antibodies  >1 publications with ProNGF and Kidney Diseases
 Fibrosis Antibodies  >1 publications with ProNGF and Fibrosis
 Weight Loss Antibodies  >1 publications with ProNGF and Weight Loss
 Inflammation Antibodies  >1 publications with ProNGF and Inflammation

Organs/Tissues associated with ProNGF recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >29 publications with ProNGF and Bone
 Nerve Antibodies  >29 publications with ProNGF and Nerve
 Eye Antibodies  >28 publications with ProNGF and Eye
 Connective Tissue Antibodies  >11 publications with ProNGF and Connective Tissue
 Blood Antibodies  >10 publications with ProNGF and Blood
 Skin Antibodies  >9 publications with ProNGF and Skin
 Brain Antibodies  >7 publications with ProNGF and Brain
 Adipose Tissue Antibodies  >5 publications with ProNGF and Adipose Tissue
 Embryonic Tissue Antibodies  >4 publications with ProNGF and Embryonic Tissue
 Lung Antibodies  >3 publications with ProNGF and Lung
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