Adolase A Kinase Antibody – Monoclonal

Aurora A is a member of the Aurora/Ipl1-related kinase family, a family of serine/threonine kinases crucial for cell cycle control. The first Aurora kinase was discovered in Drosophila(1). Mutations of this kinase caused the formation of monopolar spindles surrounded by kinase, and the appearance of this was reminiscent of the Aurora borealis at the poles of the earth. Mammals express three closely related Aurora kinases named Aurora A, Aurora B, and Aurora C.
In particular, Aurora A is overexpressed in various types of cancer and considered to play critical roles in tumorigenesis. Overexpression of Aurora A overrides the cell cycle checkpoint, interferes with mitotic exit, and induces transformation in mammalian cells. In contrast, silencing of Aurora A interrupts centrosome separation, spindle assembly and arrests G2-M transition in C. elegans and human cells. Moreover, Aurora A plays an essential role for neuronal migration by modulation of microtubule organization and is required for normal axon formation.

Small volumes of anti-Adolase A Kinase antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS555682 is an antibody targeting Adolase A Kinase. Also known as Adolase A Kinase, monoclonal antibody, mouse. Reactive in Human.