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FOXE1 Antibody – Goat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555920

FOXE1 or Forkhead box E1 is involved in thyroid morphogenesis. The protein is also expressed in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine, testis and thymus.Mutations in this gene are associated with… More details

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Product Overview

Product Name
FOXE1, Antibody
Full Product Name
FOXE1
Product Gene Name
anti-FOXE1 antibody
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity Purified
OMIM
241850
3D Structure
ModBase 3D Structure for O00358
Immunogen
Peptide with sequence C-AYPGGIDRFVSAM, from the C Terminus of the FOXE1 protein sequence according to NP_004464.2.
Applications Tested/Suitable for anti-FOXE1 antibody
Immunohistochemistry (IHC), ELISA (EIA)

Immunohistochemistry (IHC) of anti-FOXE1 antibody

FOXE1 (dilution: 2.5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on Data-sheet.
Goat Anti-FOXE1 Antibody – Cat# MBS555920

Other Notes

Small volumes of anti-FOXE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOXE1 purchase

MBS555920 is an antibody targeting FOXE1. Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXE1. It may not necessarily be applicable to this product.

NCBI GI #
21618325
NCBI GeneID
2304
NCBI Accession #
NP_004464.2
UniProt Primary Accession #
O00358
UniProt Related Accession #
O00358
GenBank Nucleotide #
NM_004473.3
NCBI Official Full Name
forkhead box protein E1
NCBI Official Synonym Full Names
forkhead box E1
NCBI Official Symbol
FOXE1
NCBI Official Synonym Symbols
TTF2; FOXE2; HFKH4; HFKL5; NMTC4; TITF2; TTF-2; FKHL15
UniProt Protein Name
Forkhead box protein E1
UniProt Synonym Protein Names
Forkhead box protein E2; Forkhead-related protein FKHL15; HFKH4; HNF-3/fork head-like protein 5; HFKL5; Thyroid transcription factor 2
Protein Family
Forkhead box protein
UniProt Gene Name
FOXE1
UniProt Synonym Gene Names
FKHL15; FOXE2; TITF2; TTF2; HFKL5; TTF-2
UniProt Entry Name
FOXE1_HUMAN
NCBI Protein Information
forkhead box protein E1

NCBI Summary for FOXE1

This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016]
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UniProt Comments for FOXE1

FOXE1: Probable transcription factor. Could be involved in thyroid gland organogenesis. Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS). BLS is associated with thyroid agenesis, cleft palate and choanal atresia.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; cell migration; hair follicle morphogenesis; thymus development; positive regulation of transcription, DNA-dependent; thyroid hormone generation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; embryonic organ morphogenesis; thyroid gland development; hard palate development; soft palate development; negative regulation of transcription, DNA-dependent

Disease: Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate; Thyroid Cancer, Nonmedullary, 4
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Research Articles on FOXE1

1. The meta-analysis revealed that common variations of FOXE1 (rs965513, rs944289 and rs1867277) were risk factors associated with increased DTC susceptibility.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-FOXE1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >5 publications with FOXE1 and Adenocarcinoma
 Bamforth syndrome Antibodies  >4 publications with FOXE1 and Bamforth syndrome
 Breast Neoplasms Antibodies  >3 publications with FOXE1 and Breast Neoplasms
 Inflammation Antibodies  >3 publications with FOXE1 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >2 publications with FOXE1 and Cell Transformation, Neoplastic
 Cysts Antibodies  >2 publications with FOXE1 and Cysts
 Hyperplasia Antibodies  >2 publications with FOXE1 and Hyperplasia
 Necrosis Antibodies  >1 publications with FOXE1 and Necrosis
 Brain Diseases Antibodies  >1 publications with FOXE1 and Brain Diseases
 Disorders of Sex Development Antibodies  >1 publications with FOXE1 and Disorders of Sex Development

Organs/Tissues associated with anti-FOXE1 antibody

 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >94 publications with FOXE1 and Thyroid
 Brain Antibodies  >8 publications with FOXE1 and Brain
 Skin Antibodies  >7 publications with FOXE1 and Skin
 Testis Antibodies  >2 publications with FOXE1 and Testis
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