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Laforin (EPM2A) Antibody – Goat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555926

Laforin is encoded bt the EMP2A gene and plays a critical role in the survival of neurons in the brain. Laforin is also expressed in many other cells throughout the body and has multiple functions. To carry out these functions, laforin interacts with several… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Laforin (EPM2A), Antibody
Full Product Name
Laforin
Product Gene Name
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity Purified
3D Structure
ModBase 3D Structure for B3EWF7
Immunogen
Synthetic peptide with sequence C-EATGHTNEMKHTTD, from the internal region of the protein sequence according to NP_005661.1.
Applications Tested/Suitable for anti-EPM2A antibody
Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-EPM2A antibody

Laforin (dilution: 2.8 ug/ml) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on data-sheet.
Goat Anti-EPM2A Antibody – Cat# MBS555926

Immunohistochemistry (IHC) of anti-EPM2A antibody

Laforin (dilution: 0.1ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-EPM2A Antibody, Immunohistochemistry (IHC) – Cat# MBS555926

Other Notes

Small volumes of anti-EPM2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPM2A purchase

MBS555926 is an antibody targeting EPM2A. Also known as Laforin. Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for EPM2A. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
Laforin, isoform 9
NCBI Official Synonym Full Names
EPM2A glucan phosphatase, laforin
NCBI Official Symbol
EPM2A
NCBI Official Synonym Symbols
EPM2; MELF
UniProt Protein Name
Laforin, isoform 9
Protein Family
UniProt Gene Name
EPM2A
NCBI Protein Information
laforin

NCBI Summary for EPM2A

This gene encodes a dual-specificity phosphatase and may be involved in the regulation of glycogen metabolism. The protein acts on complex carbohydrates to prevent glycogen hyperphosphorylation, thus avoiding the formation of insoluble aggregates. Loss-of-function mutations in this gene have been associated with Lafora disease, a rare, adult-onset recessive neurodegenerative disease, which results in myoclonus epilepsy and usually results in death several years after the onset of symptoms. The disease is characterized by the accumulation of insoluble particles called Lafora bodies, which are derived from glycogen. [provided by RefSeq, Jan 2018]
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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