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Neurogranin Precursor (NRGN) Antibody – Goat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS555927

Neurogranin is a calmodulin-binding protein expressed exclusively in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of… More details

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Product Overview

Product Name
Neurogranin Precursor (NRGN), Antibody
Full Product Name
Neurogranin Precursor
Product Gene Name
Isotype
IgG
Host
Goat
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity Purified
3D Structure
ModBase 3D Structure for Q92686
Immunogen
Peptide with sequence C-KIKSGERGRKG, from the internal region of the Neurogranin precursor protein sequence according to NP_006167.1.
Applications Tested/Suitable for anti-NRGN antibody
Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-NRGN antibody

Neurogranin precursor (dilution: 0.1ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-NRGN Antibody – Cat# MBS555927

Immunohistochemistry (IHC) of anti-NRGN antibody

Neurogranin (dilution: 4.0 ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on data-sheet.
Goat Anti-NRGN Antibody, Immunohistochemistry (IHC) – Cat# MBS555927

Other Notes

Small volumes of anti-NRGN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRGN purchase

MBS555927 is an antibody targeting NRGN. Also known as Neurogranin Precursor. Reactive in Human, Mouse, Rat. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for NRGN. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
neurogranin
NCBI Official Synonym Full Names
neurogranin
NCBI Official Symbol
NRGN
NCBI Official Synonym Symbols
RC3; hng
UniProt Protein Name
Neurogranin
UniProt Synonym Protein Names
RC3
Protein Family
UniProt Gene Name
NRGN
UniProt Synonym Gene Names
Ng
NCBI Protein Information
neurogranin

NCBI Summary for NRGN

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
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UniProt Comments for NRGN

Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium ().

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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