Mouse Anti-CRYAB; HSPB5 Monoclonal Antibody – Cat# MBS565003

Western blot analysis of alpha B Crystallin: Lane 1: MW marker, Lane 2: alpha-Crystallin, Lane 3: alpha A Crystallin, Lane 4: alpha B Crystallin, Lane 5: alpha-Crystallin.

Alpha B-Crystallin (CRYAB; HSPB5) Antibody – Mouse Monoclonal

Name: CRYAB; HSPB5 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS565003
Price: 420 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS565003

Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

alpha B-Crystallin (CRYAB; HSPB5), Monoclonal Antibody

Full Product Name

alpha B-Crystallin monoclonal antibody (1B6.1-3G4)

Product Gene Name

anti-CRYAB; HSPB5 antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

1B6.1-3G4

Host

Mouse

Species Reactivity

Human, Mouse, Rat, Bovine, Chicken

Form/Format

Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.

Purity/Purification

Protein G affinity purified.

Specificity

Recognizes human, mouse, rat, bovine and chicken alphaB-crystallin. Detects a band of ~20kDa by Western blot.

Preparation and Storage

Long term storage: -20 degree C

Molecular Weight

20,037 Da

3D Structure

ModBase 3D Structure for P02510

Immunogen

Bovine alpha B-crystallin.

Product Categories/Family for anti-CRYAB; HSPB5 antibody

Protein Synthesis & Folding

Applications Tested/Suitable for anti-CRYAB; HSPB5 antibody

Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

Application Notes for anti-CRYAB; HSPB5 antibody

Immunohistochemistry (paraffin sections, 10ug/ml)
Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~20kDa by Western blot.

Other Notes

Small volumes of anti-CRYAB; HSPB5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRYAB; HSPB5 purchase

MBS565003 is an antibody targeting CRYAB; HSPB5. Also known as alpha B-Crystallin monoclonal antibody (1B6.1-3G4). Reactive in Human, Mouse, Rat, Bovine, Chicken. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CRYAB; HSPB5. It may not necessarily be applicable to this product.

NCBI GI #

117384

NCBI GeneID

281719

NCBI Accession #

P02510.2

UniProt Primary Accession #

P02510

UniProt Secondary Accession #

O46508; Q3SZQ9

UniProt Related Accession #

P02510; AAB26923

NCBI Official Full Name

Alpha-crystallin B chain

NCBI Official Symbol

CRYAB

UniProt Protein Name

Alpha-crystallin B chain

UniProt Synonym Protein Names

Alpha(B)-crystallin

Protein Family

Alpha-crystallin

UniProt Gene Name

CRYAB

UniProt Synonym Gene Names

CRYA2

UniProt Entry Name

CRYAB_BOVIN

NCBI Protein Information

alpha-crystallin B chain

UniProt Comments for CRYAB; HSPB5

CRYAB: a major structural protein of the eye lens. A member of the small heat shock protein (sHSP also known as the HSP20) family. Alpha-B is expressed in the lens as well as other tissues. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.

Protein type: Heat shock protein; Chaperone

Cellular Component: cytoplasm; cytosol; mitochondrion; myelin sheath; nucleus; plasma membrane; Z disc

Molecular Function: metal ion binding; protein homodimerization activity; structural constituent of eye lens; unfolded protein binding

Biological Process: lens development in camera-type eye; muscle development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of intracellular transport; protein homooligomerization; response to hydrogen peroxide; response to hypoxia; tubulin folding

Research Articles on CRYAB; HSPB5

1. The alphaB-crystallin content of bovine type I muscle fibers is quantitatively similar to that in the predominantly type I fibers of rat soleus muscle.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRYAB; HSPB5 antibody

Reference Product	PubMed Publications
CRYAA antibody	>27 publications with CRYAB; HSPB5 and CRYAA
HSPB1 antibody	>23 publications with CRYAB; HSPB5 and HSPB1
CRYBB2 antibody	>15 publications with CRYAB; HSPB5 and CRYBB2
CRYBB3 antibody	>9 publications with CRYAB; HSPB5 and CRYBB3
DRD2 antibody	>2 publications with CRYAB; HSPB5 and DRD2
VEGFA antibody	>2 publications with CRYAB; HSPB5 and VEGFA
TP53 antibody	>2 publications with CRYAB; HSPB5 and TP53

Pathways associated with anti-CRYAB; HSPB5 antibody

Products by Pathway	Pathway Diagram
Longevity Regulating Pathway - Multiple Species antibodies	Longevity Regulating Pathway - Multiple Species Diagram
Longevity Regulating Pathway - Multiple Species antibodies	Longevity Regulating Pathway - Multiple Species Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-CRYAB; HSPB5 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>70 publications with CRYAB; HSPB5 and Nervous System Diseases
Cardiovascular Diseases Antibodies	>60 publications with CRYAB; HSPB5 and Cardiovascular Diseases
Heart Diseases Antibodies	>58 publications with CRYAB; HSPB5 and Heart Diseases
Cataract Antibodies	>44 publications with CRYAB; HSPB5 and Cataract
Brain Diseases Antibodies	>26 publications with CRYAB; HSPB5 and Brain Diseases
Neurodegenerative Diseases Antibodies	>21 publications with CRYAB; HSPB5 and Neurodegenerative Diseases
Breast Neoplasms Antibodies	>16 publications with CRYAB; HSPB5 and Breast Neoplasms
Inflammation Antibodies	>15 publications with CRYAB; HSPB5 and Inflammation
Necrosis Antibodies	>11 publications with CRYAB; HSPB5 and Necrosis
Neurobehavioral Manifestations Antibodies	>5 publications with CRYAB; HSPB5 and Neurobehavioral Manifestations

Organs/Tissues associated with anti-CRYAB; HSPB5 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>91 publications with CRYAB; HSPB5 and Muscle
Brain Antibodies	>44 publications with CRYAB; HSPB5 and Brain
Lens Antibodies	>39 publications with CRYAB; HSPB5 and Lens
Lung Antibodies	>8 publications with CRYAB; HSPB5 and Lung
Embryonic Tissue Antibodies	>6 publications with CRYAB; HSPB5 and Embryonic Tissue
Liver Antibodies	>3 publications with CRYAB; HSPB5 and Liver
Kidney Antibodies	>3 publications with CRYAB; HSPB5 and Kidney
Ovary Antibodies	>2 publications with CRYAB; HSPB5 and Ovary
Whole Body Antibodies	>2 publications with CRYAB; HSPB5 and Whole Body
Uncharacterized Tissue Antibodies	>1 publications with CRYAB; HSPB5 and Uncharacterized Tissue