Mouse Anti-SARM Monoclonal Antibody – Cat# MBS565016

SARM Antibody – Mouse Monoclonal

Name: SARM Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS565016
Price: 635 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS565016

In mammals, TIR domain adapters, including Myd88, TIRAP, TICAM-1 (also called TRIF), and TRAM, act in Toll-like receptor (TLR) signaling pathway. The last member of this family called SARM (sterile and armadillo motifs) is highly conserved but has no known… More details

$635 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SARM, Monoclonal Antibody

Full Product Name

SARM (human) monoclonal antibody (Sarmy-1)

Product Gene Name

anti-SARM antibody

Product Synonym Names

TIR-1; Sterile alpha and TIR motif-containing protein 1; SAM and ARM-containing protein; Sterile alpha motif and armadillo repeat-containing protein

Clonality

Monoclonal

Isotype

IgG2b

Host

Mouse; Purified from concentrated hybridoma tissue culture supernatant.

Species Reactivity

Human

Form/Format

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Specificity

Recognizes human SARM.

Preparation and Storage

Long term: Stable for at least 1 year after receipt when stored at -20 degree C.
Short term: 4 degree C
Avoid freeze/thaw cycles.

Molecular Weight

75,337 Da

OMIM

607732

3D Structure

ModBase 3D Structure for Q6SZW1

Immunogen

Recombinant human SARM (aa 93-292).

Product Categories/Family for anti-SARM antibody

Cell Signaling

Applications Tested/Suitable for anti-SARM antibody

Immunoprecipitation (IP)

Application Notes for anti-SARM antibody

Immunoprecipitation (1:200)
Suggested dilutions/conditions may not be available for all applications.
Does not work for Western Blot.

Other Notes

Small volumes of anti-SARM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SARM purchase

MBS565016 is an antibody targeting SARM. Also known as SARM (human) monoclonal antibody (Sarmy-1). Reactive in Human. Host: Mouse; Purified from concentrated hybridoma tissue culture supernatant.

Additional Details

NCBI/Uniprot data below describe general gene information for SARM. It may not necessarily be applicable to this product.

NCBI GI #

83288284

NCBI GeneID

23098

NCBI Accession #

Q6SZW1.1

UniProt Primary Accession #

Q6SZW1

UniProt Secondary Accession #

O60277; Q7LGG3; Q9NXY5

UniProt Related Accession #

Q6SZW1

NCBI Official Full Name

Sterile alpha and TIR motif-containing protein 1

NCBI Official Synonym Full Names

sterile alpha and TIR motif containing 1

NCBI Official Symbol

SARM1

NCBI Official Synonym Symbols

SARM; SAMD2; MyD88-5

UniProt Protein Name

Sterile alpha and TIR motif-containing protein 1

UniProt Synonym Protein Names

Sterile alpha and Armadillo repeat protein; Sterile alpha motif domain-containing protein 2; MyD88-5; SAM domain-containing protein 2; Tir-1 homolog

UniProt Gene Name

SARM1

UniProt Synonym Gene Names

KIAA0524; SAMD2; SARM; MyD88-5; SAM domain-containing protein 2

UniProt Entry Name

SARM1_HUMAN

NCBI Protein Information

sterile alpha and TIR motif-containing protein 1

UniProt Comments for SARM

SARM1: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: axon; cell junction; cytoplasm; cytosol; dendrite; extrinsic to mitochondrial outer membrane; microtubule; mitochondrion; synapse

Biological Process: innate immune response; MyD88-independent toll-like receptor signaling pathway; regulation of apoptosis; regulation of dendrite morphogenesis; response to glucose stimulus; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway

Research Articles on SARM

1. These results indicate that association of PINK1 with SARM1 and TRAF6 is an important step for mitophagy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SARM antibody

Reference Product	PubMed Publications
MYD88 antibody	>19 publications with SARM and MYD88
SDC2 antibody	>1 publications with SARM and SDC2
UXT antibody	>1 publications with SARM and UXT

Pathways associated with anti-SARM antibody

Products by Pathway	Pathway Diagram
Activated TLR4 Signalling Pathway antibodies	Activated TLR4 Signalling Pathway Diagram
Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies	Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
IKK Complex Recruitment Mediated By RIP1 Pathway antibodies	IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
MyD88-independent TLR3/TLR4 Cascade Pathway antibodies	MyD88-independent TLR3/TLR4 Cascade Pathway Diagram
TRAF6 Mediated Induction Of TAK1 Complex Pathway antibodies	TRAF6 Mediated Induction Of TAK1 Complex Pathway Diagram
TRIF-mediated TLR3/TLR4 Signaling Pathway antibodies	TRIF-mediated TLR3/TLR4 Signaling Pathway Diagram
Toll Like Receptor 3 (TLR3) Cascade Pathway antibodies	Toll Like Receptor 3 (TLR3) Cascade Pathway Diagram
Toll Like Receptor 4 (TLR4) Cascade Pathway antibodies	Toll Like Receptor 4 (TLR4) Cascade Pathway Diagram

Diseases associated with anti-SARM antibody

Disease Name	Pubmed Publications
Nerve Degeneration Antibodies	>9 publications with SARM and Nerve Degeneration
Nervous System Diseases Antibodies	>7 publications with SARM and Nervous System Diseases
Inflammation Antibodies	>7 publications with SARM and Inflammation
Necrosis Antibodies	>5 publications with SARM and Necrosis
Disease Models, Animal Antibodies	>3 publications with SARM and Disease Models, Animal
Brain Injuries Antibodies	>2 publications with SARM and Brain Injuries
Kidney Diseases Antibodies	>2 publications with SARM and Kidney Diseases
Cognition Disorders Antibodies	>1 publications with SARM and Cognition Disorders
Respiratory Syncytial Virus Infections Antibodies	>1 publications with SARM and Respiratory Syncytial Virus Infections

Organs/Tissues associated with anti-SARM antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>14 publications with SARM and Brain
Eye Antibodies	>5 publications with SARM and Eye
Kidney Antibodies	>5 publications with SARM and Kidney
Ganglia Antibodies	>4 publications with SARM and Ganglia
Spleen Antibodies	>2 publications with SARM and Spleen
Bone Antibodies	>1 publications with SARM and Bone
Muscle Antibodies	>1 publications with SARM and Muscle
Intestine Antibodies	>1 publications with SARM and Intestine
Lung Antibodies	>1 publications with SARM and Lung