Mouse Anti-UNC5A Monoclonal Antibody – Cat# MBS565063

UNC5A Antibody – Mouse Monoclonal

Name: UNC5A Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS565063
Price: 685 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS565063

MBS565063 is an antibody targeting UNC5A. Also known as UNC5A (human) monoclonal antibody (Dettwy-1). Reactive in Human. Host: Mouse: Purified from concentrated hybridoma tissue cell culture supernatant. More details

$685 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

UNC5A, Monoclonal Antibody

Full Product Name

UNC5A (human) monoclonal antibody (Dettwy-1)

Product Gene Name

anti-UNC5A antibody

Product Synonym Names

Netrin receptor UNC5A precursor; UNC5H1; UNC-5 homolog A; UNC-5 homolog 1

Clonality

Monoclonal

Isotype

IgG1

Clone Number

Dettwy-1

Host

Mouse: Purified from concentrated hybridoma tissue cell culture supernatant.

Species Reactivity

Human

Form/Format

Liquid. In PBS containing 0.02% sodium azide.

Purity/Purification

Protein G-affinity purified.

Specificity

Recognizes human UNC5A.

Preparation and Storage

Long term storage: Aliquot and freeze at -20 degree C. Avoid freeze/thaw cycles.
Short term: 4 degree C

Molecular Weight

88,640 Da

OMIM

607869

3D Structure

ModBase 3D Structure for Q6ZN44

Immunogen

Extracellular domain of human UNC5A (aa 26-306) fused to the Fc portion of human IgG1.

Product Categories/Family for anti-UNC5A antibody

Cell Signaling

Applications Tested/Suitable for anti-UNC5A antibody

ELISA (EIA), Flow Cytometry (FC/FACS)

Other Notes

Small volumes of anti-UNC5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UNC5A. It may not necessarily be applicable to this product.

NCBI GI #

296453000

NCBI GeneID

90249

NCBI Accession #

Q6ZN44.3

UniProt Primary Accession #

Q6ZN44

UniProt Secondary Accession #

Q8TF26; Q96GP4; B2RXE6

UniProt Related Accession #

Q6ZN44

NCBI Official Full Name

Netrin receptor UNC5A

NCBI Official Synonym Full Names

unc-5 netrin receptor A

NCBI Official Symbol

UNC5A

NCBI Official Synonym Symbols

UNC5H1

UniProt Protein Name

Netrin receptor UNC5A

UniProt Synonym Protein Names

Protein unc-5 homolog 1; Protein unc-5 homolog A

Protein Family

Netrin receptor

UniProt Gene Name

UNC5A

UniProt Synonym Gene Names

KIAA1976; UNC5H1

UniProt Entry Name

UNC5A_HUMAN

NCBI Protein Information

netrin receptor UNC5A

NCBI Summary for UNC5A

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]

UniProt Comments for UNC5A

UNC5A: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Belongs to the unc-5 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: integral to membrane; intrinsic to plasma membrane; lipid raft; plasma membrane

Biological Process: anterior/posterior axon guidance; apoptosis; axon guidance; neurite development; programmed cell death

Research Articles on UNC5A

1. FANCC interferes with UNC5A's functions in apoptosis and suggest that FANCC may participate in developmental processes through association with the dependence receptor UNC5A.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UNC5A antibody

Reference Product	PubMed Publications
DCC antibody	>17 publications with UNC5A and DCC
UNC5B antibody	>15 publications with UNC5A and UNC5B
UNC5C antibody	>13 publications with UNC5A and UNC5C
UNC5D antibody	>7 publications with UNC5A and UNC5D
RHOA antibody	>2 publications with UNC5A and RHOA
NTN4 antibody	>2 publications with UNC5A and NTN4
CASP3 antibody	>1 publications with UNC5A and CASP3
RAC1 antibody	>1 publications with UNC5A and RAC1
NTN1 antibody	>1 publications with UNC5A and NTN1

Pathways associated with anti-UNC5A antibody

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Caspase Activation Via Extrinsic Apoptotic Signalig Pathway antibodies	Caspase Activation Via Extrinsic Apoptotic Signalig Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Ligand-independent Caspase Activation Via DCC Pathway antibodies	Ligand-independent Caspase Activation Via DCC Pathway Diagram
Netrin Mediated Repulsion Signals Pathway antibodies	Netrin Mediated Repulsion Signals Pathway Diagram
Netrin-1 Signaling Pathway antibodies	Netrin-1 Signaling Pathway Diagram
Programmed Cell Death Pathway antibodies	Programmed Cell Death Pathway Diagram

Diseases associated with anti-UNC5A antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>3 publications with UNC5A and Disease Models, Animal
Inflammation Antibodies	>3 publications with UNC5A and Inflammation
Metaplasia Antibodies	>1 publications with UNC5A and Metaplasia
Embryo Loss Antibodies	>1 publications with UNC5A and Embryo Loss
Cell Transformation, Neoplastic Antibodies	>1 publications with UNC5A and Cell Transformation, Neoplastic
Lung Neoplasms Antibodies	>1 publications with UNC5A and Lung Neoplasms
Breast Neoplasms Antibodies	>1 publications with UNC5A and Breast Neoplasms
Kidney Diseases Antibodies	>1 publications with UNC5A and Kidney Diseases

Organs/Tissues associated with anti-UNC5A antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>11 publications with UNC5A and Brain
Blood Antibodies	>2 publications with UNC5A and Blood
Eye Antibodies	>2 publications with UNC5A and Eye
Mouth Antibodies	>1 publications with UNC5A and Mouth
Ovary Antibodies	>1 publications with UNC5A and Ovary