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CCT; p63; TRIC; T-complex 1 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS565075

TCP-1alpha is a 60 kDa subunit of a cytosolic hetero-oligomer chaperone that is known to be involved in the folding of Actin and Tubulin. This protein is a member of the Chaperonin family, which includes E Coli GroEL, the mitochondrial Heat-shock protein… More details

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Product Overview

Product Name
TCP-1 beta (CCT; p63; Tric; T-complex 1), Monoclonal Antibody
Full Product Name
TCP-1 beta monoclonal antibody (PK/8/4/4i/2f)
Product Gene Name
anti-CCT; p63; Tric; T-complex 1 antibody
Product Synonym Names
TCP-1 beta
Clonality
Monoclonal
Isotype
IgG2b
Host
Rat
Species Reactivity
Human, Mouse, Rat, Bovine, Chicken, Dog, Hamster, Monkey, Porcine, Rabbit, Sheep
Form/Format
Liquid. In PBS, pH 7.2, containing 10mM sodium phosphate, 50mM sodium chloride, and 0.1mM PMSF.
Purity/Purification
Protein G affinity purified.
Specificity
Recognizes human, mouse, rat, bovine, dog, chicken, hamster, monkey, pig, rabbit and sheep TCP-1beta. Detects a band of ~55kDa by Western blot.
Preparation and Storage
Long term storage: -20 degree C
Avoid freeze/thaw cycles.
Molecular Weight
57,477 Da
3D Structure
ModBase 3D Structure for P80314
Immunogen
Mouse CCT beta peptide - PPD conjugate.

Product Categories/Family for anti-CCT; p63; Tric; T-complex 1 antibody

Protein Synthesis & Folding
Applications Tested/Suitable for anti-CCT; p63; Tric; T-complex 1 antibody
Immunohistochemistry (IHC) (PS), Western Blot (WB)
Application Notes for anti-CCT; p63; Tric; T-complex 1 antibody
Western Blot (1ug/ml, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~55kDa by Western blot.

Western Blot (WB) of anti-CCT; p63; Tric; T-complex 1 antibody

Western blot analysis of human Jurkat cell lysate probed with TCP-1 beta mAb (PK/8/4/4i/2f).
Rat Anti-CCT; p63; TRIC; T-complex 1 Monoclonal Antibody – Cat# MBS565075

Other Notes

Small volumes of anti-CCT; p63; Tric; T-complex 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCT; p63; Tric; T-complex 1 purchase

MBS565075 is an antibody targeting CCT; p63; Tric; T-complex 1. Also known as TCP-1 beta monoclonal antibody (PK/8/4/4i/2f). Reactive in Human, Mouse, Rat, Bovine, Chicken, Dog, Hamster, Monkey, Porcine, Rabbit, Sheep. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CCT; p63; Tric; T-complex 1. It may not necessarily be applicable to this product.

NCBI GI #
22654291
NCBI GeneID
12461
NCBI Accession #
P80314.4
UniProt Primary Accession #
P80314
UniProt Secondary Accession #
Q9R1U0
UniProt Related Accession #
P80314
NCBI Official Full Name
T-complex protein 1 subunit beta
NCBI Official Synonym Full Names
chaperonin containing Tcp1, subunit 2 (beta)
NCBI Official Symbol
Cct2
NCBI Official Synonym Symbols
Cctb
UniProt Protein Name
T-complex protein 1 subunit beta
UniProt Synonym Protein Names
CCT-beta
Protein Family
T-complex protein
UniProt Gene Name
Cct2
UniProt Synonym Gene Names
Cctb; TCP-1-beta
UniProt Entry Name
TCPB_MOUSE
NCBI Protein Information
T-complex protein 1 subunit beta

UniProt Comments for CCT; p63; Tric; T-complex 1

CCT2: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Belongs to the TCP-1 chaperonin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Chaperone

Cellular Component: chaperonin-containing T-complex; cytoplasm; microtubule; myelin sheath

Molecular Function: ATP binding; nucleotide binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: binding of sperm to zona pellucida; chaperone cofactor-independent protein folding; chaperone-mediated protein complex assembly; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein folding; protein stabilization
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Research Articles on CCT; p63; Tric; T-complex 1

1. role of chaperonin-containing t-complex polypeptide 1 beta (CCT2) in the regulation of mesangial cell contraction, proliferation, and migration with filamentous/globular-(F/G-) actin ratio under high glucose induction

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCT; p63; Tric; T-complex 1 antibody

 Reference Product  PubMed Publications
 Tcp1 antibody  >9 publications with CCT; p63; Tric; T-complex 1 and Tcp1
 Cct3 antibody  >5 publications with CCT; p63; Tric; T-complex 1 and Cct3
 Cct4 antibody  >4 publications with CCT; p63; Tric; T-complex 1 and Cct4
 Cct5 antibody  >2 publications with CCT; p63; Tric; T-complex 1 and Cct5
 Cct8 antibody  >1 publications with CCT; p63; Tric; T-complex 1 and Cct8
 Cct7 antibody  >1 publications with CCT; p63; Tric; T-complex 1 and Cct7
 Cct6a antibody  >1 publications with CCT; p63; Tric; T-complex 1 and Cct6a

Pathways associated with anti-CCT; p63; Tric; T-complex 1 antibody

 Products by Pathway  Pathway Diagram
 Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies  Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Protein Folding Pathway antibodies  Protein Folding Pathway Diagram

Diseases associated with anti-CCT; p63; Tric; T-complex 1 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >6 publications with CCT; p63; Tric; T-complex 1 and Carcinoma
 Adenocarcinoma Antibodies  >4 publications with CCT; p63; Tric; T-complex 1 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >3 publications with CCT; p63; Tric; T-complex 1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with CCT; p63; Tric; T-complex 1 and Liver Neoplasms
 Inflammation Antibodies  >2 publications with CCT; p63; Tric; T-complex 1 and Inflammation
 Lung Neoplasms Antibodies  >1 publications with CCT; p63; Tric; T-complex 1 and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with CCT; p63; Tric; T-complex 1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >1 publications with CCT; p63; Tric; T-complex 1 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >1 publications with CCT; p63; Tric; T-complex 1 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >1 publications with CCT; p63; Tric; T-complex 1 and Kidney Diseases

Organs/Tissues associated with anti-CCT; p63; Tric; T-complex 1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with CCT; p63; Tric; T-complex 1 and Blood
 Brain Antibodies  >4 publications with CCT; p63; Tric; T-complex 1 and Brain
 Liver Antibodies  >2 publications with CCT; p63; Tric; T-complex 1 and Liver
 Lung Antibodies  >2 publications with CCT; p63; Tric; T-complex 1 and Lung
 Eye Antibodies  >2 publications with CCT; p63; Tric; T-complex 1 and Eye
 Spinal Cord Antibodies  >2 publications with CCT; p63; Tric; T-complex 1 and Spinal Cord
 Intestine Antibodies  >2 publications with CCT; p63; Tric; T-complex 1 and Intestine
 Kidney Antibodies  >2 publications with CCT; p63; Tric; T-complex 1 and Kidney
 Bone Antibodies  >2 publications with CCT; p63; Tric; T-complex 1 and Bone
 Prostate Antibodies  >1 publications with CCT; p63; Tric; T-complex 1 and Prostate
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