BIRC5; EPR1 Antibody – Mouse Monoclonal

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: centriole; chromosome, pericentric region; cytoplasm; cytoplasmic microtubule; cytosol; interphase microtubule organizing center; microtubule; midbody; nuclear chromosome; nucleoplasm; nucleus; spindle; spindle microtubule

Molecular Function: caspase inhibitor activity; chaperone binding; cobalt ion binding; cofactor binding; cysteine protease inhibitor activity; enzyme binding; identical protein binding; metal ion binding; microtubule binding; protein binding; protein heterodimerization activity; protein homodimerization activity; Ran GTPase binding; tubulin binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: cell division; cellular protein metabolic process; chromosome segregation; cytokinesis; establishment of chromosome localization; G2/M transition of mitotic cell cycle; mitosis; mitotic cell cycle; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of exit from mitosis; positive regulation of mitotic cell cycle; post-translational protein modification; protein amino acid phosphorylation; protein complex localization; protein sumoylation; protein ubiquitination; regulation of signal transduction; small GTPase mediated signal transduction; spindle checkpoint; transcription, DNA-dependent