Calcineurin A (PPP3CB) Antibody – Rabbit Polyclonal

PPP3CB: a calmodulin-dependent Ser/Thr phosphatase also known calcineurin A beta. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively.

Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: calcineurin complex; cytosol; nucleoplasm; plasma membrane; T-tubule; Z disc

Molecular Function: calcium ion binding; calmodulin binding; calmodulin-dependent protein phosphatase activity; drug binding; enzyme binding; protein binding; protein dimerization activity; protein phosphatase 2B binding; protein serine/threonine phosphatase activity

Biological Process: axon extension; calcineurin-NFAT signaling pathway; calcium ion-dependent exocytosis; dephosphorylation; heart development; innate immune response; learning; locomotion during locomotory behavior; lymphangiogenesis; memory; negative regulation of T cell mediated cytotoxicity; positive regulation of NFAT protein import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid dephosphorylation; protein amino acid phosphorylation; regulation of insulin secretion; regulation of synaptic plasticity; response to cytokine stimulus; signal transduction; social behavior; stimulatory C-type lectin receptor signaling pathway; T cell activation; T cell differentiation; T cell homeostasis; T cell proliferation