TGF- beta -activated kinase-1 Antibody – Rabbit Polyclonal

TAK1: a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described.

Protein type: Protein kinase, TKL; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; MLK family; TAK1 subfamily

Cellular Component: cytoplasm; intracellular; membrane; plasma membrane

Molecular Function: ATP binding; kinase activity; MAP kinase kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity

Biological Process: activation of MAPKK activity; angiogenesis; apoptosis; I-kappaB phosphorylation; MAPKKK cascade; neural tube formation; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway