Rabbit Anti-MtHsp70; HSP70 (mitochondrial); HspA9 Polyclonal Antibody – Cat# MBS565235

Western blot analysis of Grp75 (Mortalin): Lane 1: MW marker, Lane 2: HeLa cell lysate, heat shocked, Lane 3: RK-13 cell lysate, heat shocked, Lane 4: 3T3 cell lysate heat shocked, Lane 5: PC-12 cell lysate heat shocked.

MtHsp70; HSP70 (mitochondrial); HspA9 Antibody – Rabbit Polyclonal

Name: MtHsp70; HSP70 (mitochondrial); HspA9 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS565235
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS565235

Cells from various organisms increase expression of a class of proteins referred to as heat shock or stress proteins in response to adverse changes in their environment. The members of one class of stress proteins, the Hsp70 family, all bind ATP in vitro, but… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Grp75/Mortalin (MtHsp70; Hsp70 (mitochondrial); HspA9), Polyclonal Antibody

Full Product Name

Grp75/Mortalin polyclonal antibody

Product Gene Name

anti-MtHsp70; Hsp70 (mitochondrial); HspA9 antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Monkey, Rabbit

Form/Format

Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.

Purity/Purification

Protein A affinity purified.

Specificity

Recognizes human, mouse, rat, bovine, dog, guinea pig, hamster, monkey and rabbit Grp75. Detects a band of ~75kDa by Western blot.

Preparation and Storage

Long term storage: -20 degree C
Avoid freeze/thaw cycles.

Molecular Weight

73,680 Da

OMIM

600548

3D Structure

ModBase 3D Structure for P38646

Immunogen

Synthetic peptide corresponding to the middle of human Grp75 (mortalin).

Product Categories/Family for anti-MtHsp70; Hsp70 (mitochondrial); HspA9 antibody

Cell Signaling; Cell Organelles & Structures; Protein Synthesis & Folding

Applications Tested/Suitable for anti-MtHsp70; Hsp70 (mitochondrial); HspA9 antibody

Western Blot (WB)

Application Notes for anti-MtHsp70; Hsp70 (mitochondrial); HspA9 antibody

Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~75kDa by Western blot.

Other Notes

Small volumes of anti-MtHsp70; Hsp70 (mitochondrial); HspA9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MtHsp70; Hsp70 (mitochondrial); HspA9 purchase

MBS565235 is an antibody targeting MtHsp70; Hsp70 (mitochondrial); HspA9. Also known as Grp75/Mortalin polyclonal antibody. Reactive in Human, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Monkey, Rabbit. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MtHsp70; Hsp70 (mitochondrial); HspA9. It may not necessarily be applicable to this product.

NCBI GI #

21264428

NCBI GeneID

3313

NCBI Accession #

P38646.2

UniProt Primary Accession #

P38646

UniProt Secondary Accession #

P30036; P31932; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56; B2RCM1

UniProt Related Accession #

P38646

NCBI Official Full Name

Stress-70 protein, mitochondrial

NCBI Official Synonym Full Names

heat shock protein family A (Hsp70) member 9

NCBI Official Symbol

HSPA9

NCBI Official Synonym Symbols

CSA; MOT; MOT2; SAAN; CRP40; EVPLS; GRP75; PBP74; GRP-75; HSPA9B; MTHSP75; HEL-S-124m

UniProt Protein Name

Stress-70 protein, mitochondrial

UniProt Synonym Protein Names

75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; MOT; Peptide-binding protein 74; PBP74

UniProt Gene Name

HSPA9

UniProt Synonym Gene Names

GRP75; HSPA9B; mt-HSP70; GRP-75; MOT; PBP74

UniProt Entry Name

GRP75_HUMAN

NCBI Protein Information

stress-70 protein, mitochondrial

NCBI Summary for MtHsp70; Hsp70 (mitochondrial); HspA9

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

UniProt Comments for MtHsp70; Hsp70 (mitochondrial); HspA9

HSPA9B: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Belongs to the heat shock protein 70 family.

Protein type: Nucleolus; Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cytoplasm; focal adhesion; mitochondrion; myelin sheath; nucleolus

Molecular Function: ATP binding; fibroblast growth factor binding; heat shock protein binding; protein binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: cellular protein metabolic process; negative regulation of apoptosis; protein export from nucleus; protein folding; protein targeting to mitochondrion; response to toxin

Research Articles on MtHsp70; Hsp70 (mitochondrial); HspA9

1. Expression of mortalin decreased significantly in dopaminergic cells overexpressing A53T alpha-syn

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MtHsp70; Hsp70 (mitochondrial); HspA9 antibody

Reference Product	PubMed Publications
TP53 antibody	>7 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and TP53
DNLZ antibody	>2 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and DNLZ
UBC antibody	>1 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and UBC
DNAJA3 antibody	>1 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and DNAJA3

Pathways associated with anti-MtHsp70; Hsp70 (mitochondrial); HspA9 antibody

Products by Pathway	Pathway Diagram
Cellular Response To Heat Stress Pathway antibodies	Cellular Response To Heat Stress Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Mitochondrial Protein Import Pathway antibodies	Mitochondrial Protein Import Pathway Diagram
Parkin-Ubiquitin Proteasomal System Pathway antibodies	Parkin-Ubiquitin Proteasomal System Pathway Diagram
RNA Degradation Pathway antibodies	RNA Degradation Pathway Diagram
RNA Degradation Pathway antibodies	RNA Degradation Pathway Diagram
Regulation Of HSF1-mediated Heat Shock Response Pathway antibodies	Regulation Of HSF1-mediated Heat Shock Response Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram

Diseases associated with anti-MtHsp70; Hsp70 (mitochondrial); HspA9 antibody

Disease Name	Pubmed Publications
Cell Transformation, Neoplastic Antibodies	>11 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Cell Transformation, Neoplastic
Nervous System Diseases Antibodies	>10 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Nervous System Diseases
Parkinson Disease Antibodies	>6 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Parkinson Disease
Neoplasms, Experimental Antibodies	>5 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Neoplasms, Experimental
Carcinoma, Hepatocellular Antibodies	>5 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>4 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Liver Neoplasms
Liver Diseases Antibodies	>4 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Liver Diseases
Cardiovascular Diseases Antibodies	>3 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Cardiovascular Diseases
Inflammation Antibodies	>2 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Inflammation
Anemia Antibodies	>2 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Anemia

Organs/Tissues associated with anti-MtHsp70; Hsp70 (mitochondrial); HspA9 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Blood
Brain Antibodies	>10 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Brain
Liver Antibodies	>9 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Liver
Bone Antibodies	>7 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Bone
Lung Antibodies	>5 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Lung
Bone Marrow Antibodies	>4 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Bone Marrow
Skin Antibodies	>4 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Skin
Vascular Antibodies	>3 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Vascular
Kidney Antibodies	>2 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Kidney
Pancreas Antibodies	>2 publications with MtHsp70; Hsp70 (mitochondrial); HspA9 and Pancreas