TPN; TPSN; TAP binding protein Antibody – Rabbit Polyclonal

This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TAPBP: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; integral to membrane; TAP complex

Molecular Function: MHC class I protein binding; peptide antigen binding; peptide antigen-transporting ATPase activity; protein binding; TAP1 binding; TAP2 binding; unfolded protein binding

Biological Process: amide transport; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; immune response; peptide antigen stabilization; peptide transport; protein complex assembly; regulation of gene expression; retrograde vesicle-mediated transport, Golgi to ER

Disease: Bare Lymphocyte Syndrome, Type I