NBR1 Antibody – Rabbit Polyclonal

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

NBR1: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Homooligomer and heterooligomer. Interacts with TRIM55. Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: autophagic vacuole; cytoplasmic vesicle; cytosol; late endosome; lysosome; M band; membrane; mitochondrion

Molecular Function: mitogen-activated protein kinase binding; protein binding; ubiquitin binding; zinc ion binding

Biological Process: macroautophagy; negative regulation of osteoblast differentiation; protein oligomerization; regulation of bone mineralization; regulation of stress-activated MAPK cascade