NK1r; SUBSTANCE P receptor Antibody – Rabbit Polyclonal

TACR1: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Cellular Component: cell surface; cytoplasm; cytosol; dendrite; integral to plasma membrane; plasma membrane

Molecular Function: substance P receptor activity

Biological Process: acute inflammatory response; angiotensin mediated drinking behavior; associative learning; behavioral response to pain; cell surface receptor linked signal transduction; eating behavior; elevation of cytosolic calcium ion concentration; learning and/or memory; long-term memory; neuropeptide signaling pathway; operant conditioning; positive regulation of action potential; positive regulation of blood pressure; positive regulation of epithelial cell proliferation; positive regulation of hormone secretion; positive regulation of leukocyte migration; positive regulation of lymphocyte proliferation; positive regulation of ossification; positive regulation of saliva secretion; positive regulation of stress fiber formation; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, GABAergic; positive regulation of vascular permeability; positive regulation of vasoconstriction; regulation of blood pressure; regulation of smooth muscle cell migration; regulation of smooth muscle cell proliferation; response to electrical stimulus; response to estradiol stimulus; response to ethanol; response to heat; response to hormone stimulus; response to morphine; response to nicotine; response to organic cyclic substance; response to ozone; response to pain; response to progesterone stimulus; sensory perception of pain; smooth muscle contraction involved in micturition; sperm ejaculation; tachykinin signaling pathway