Hepsin (HPN) Antibody – Mouse Monoclonal

This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

HPN: Plays an essential role in cell growth and maintenance of cell morphology. Belongs to the peptidase S1 family.

Protein type: Membrane protein, integral; EC 3.4.21.106; Protease

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: endoplasmic reticulum membrane; nuclear membrane; cell surface; cell soma; integral to plasma membrane; plasma membrane; integral to membrane; intercellular junction

Molecular Function: peptidase activity; calcium-activated potassium channel activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: regulation of cell shape; cholesterol homeostasis; detection of mechanical stimulus involved in sensory perception of sound; proteolysis; positive regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of apoptosis