Diglycyl Lysine Antibody – Mouse Monoclonal

Protein ubiquitination is a fundamentally important post-translational modification that regulates myriad cell signaling pathways in eukaryotes. Alterations in protein ubiquitination have been linked to cancers and neurodegenerative, cardiovascular, immunological, and inflammatory diseases.

Identification of exact ubiquitinylation sites is challenging under physiological conditions, but the recent development of an immunoprecipitation approach allows for enrichment and identification of peptides derived from the ubiquitinated portion of proteins.

When ubiquitinated protein is digested with trypsin a diglycine residue remains at any lysine site of ubiquitin attachment. Diglycyl Lysine, mAb (GX41) facilitates easy capture and enrichment of peptides derived from ubiquitinated proteins by recognizing the diglycyl-lysine residue with no detectable reactivity to non modified lysines.

Small volumes of anti-Diglycyl Lysine antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS565861 is an antibody targeting Diglycyl Lysine. Also known as Diglycyl Lysine monoclonal antibody (GX41). Reactive in General. Host: Mouse.