HIP Recombinant Protein

Name: HIP Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS565966
Price: 545 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS565966

Hsc70-interacting protein (Hip) is a cytosolic protein that exists as a homo-oligomer and participates in the regulation of the heat shock protein Hsc70 in eukaryotic cells. Hip interacts with the ATPase domain of Hsc70 molecules through the tetratricopeptide… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Hip, Recombinant Protein

Full Product Name

Hip (rat), (recombinant)

Product Gene Name

Hip recombinant protein

Host

E Coli

Form/Format

Liquid. In 20mM MOPS, pH7.2, containing 50mM sodium chloride and 2mM magnesium chloride

Purity/Purification

>=85% (SDS-PAGE; Western blot)
Purified by multi-step chromatography

Preparation and Storage

For long term storage, store at -80 degree C
Shipping: Shipped on Dry Ice

Molecular Weight

41,280 Da

3D Structure

ModBase 3D Structure for P50503

Product Categories/Family for Hip recombinant protein

Proteostasis; Protein Synthesis & Folding

Applications Tested/Suitable for Hip recombinant protein

Western Blot (WB)

Other Notes

Small volumes of Hip recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hip purchase

MBS565966 is a recombinant protein targeting Hip. Also known as Hip (rat), (recombinant). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Hip. It may not necessarily be applicable to this product.

NCBI GI #

1708200

NCBI GeneID

81800

NCBI Accession #

P50503.1

UniProt Primary Accession #

P50503

UniProt Related Accession #

P50503

NCBI Official Full Name

Hsc70-interacting protein

NCBI Official Synonym Full Names

suppression of tumorigenicity 13

NCBI Official Symbol

St13

UniProt Protein Name

Hsc70-interacting protein

UniProt Synonym Protein Names

Protein FAM10A1; Protein ST13 homolog

Protein Family

High-potential iron-sulfur protein

UniProt Gene Name

St13

UniProt Synonym Gene Names

Fam10a1; Hip; Hip

UniProt Entry Name

F10A1_RAT

NCBI Protein Information

hsc70-interacting protein

NCBI Summary for Hip

cochaperone protein; involved in regulation of the heat shock protein, Hsc70 [RGD, Feb 2006]

UniProt Comments for Hip

HIP: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90. Interacts (via the C-terminus 303- 319 AA) with GRK5. Belongs to the FAM10 family.

Protein type: Chaperone; Adaptor/scaffold

Cellular Component: cytoplasm; cytosol; protein complex

Molecular Function: chaperone binding; dATP binding; Hsp70 protein binding; identical protein binding; protein complex binding; protein domain specific binding; unfolded protein binding

Biological Process: protein folding; protein homooligomerization

Research Articles on Hip

1. The tetratricopeptide repeat domain of rat Hip with the Hsp70 ATPase domain through an extensive interface, to form a bracket that locks ADP in the binding cleft.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Hip recombinant protein

Reference Product	PubMed Publications
St5 recombinant protein	>4 publications with Hip and St5
St14 recombinant protein	>4 publications with Hip and St14
St18 recombinant protein	>1 publications with Hip and St18
Hsp90aa1 recombinant protein	>1 publications with Hip and Hsp90aa1

Diseases associated with Hip recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>5 publications with Hip and Nervous System Diseases
Movement Disorders Antibodies	>4 publications with Hip and Movement Disorders
Liver Neoplasms Antibodies	>1 publications with Hip and Liver Neoplasms
Skin Diseases Antibodies	>1 publications with Hip and Skin Diseases
Neoplasms, Experimental Antibodies	>1 publications with Hip and Neoplasms, Experimental
Liver Diseases Antibodies	>1 publications with Hip and Liver Diseases
Cardiovascular Diseases Antibodies	>1 publications with Hip and Cardiovascular Diseases
Nerve Degeneration Antibodies	>1 publications with Hip and Nerve Degeneration
Fibrosis Antibodies	>1 publications with Hip and Fibrosis
Necrosis Antibodies	>1 publications with Hip and Necrosis

Organs/Tissues associated with Hip recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>2 publications with Hip and Lung
Brain Antibodies	>2 publications with Hip and Brain
Embryonic Tissue Antibodies	>1 publications with Hip and Embryonic Tissue