MMP-24 Active Protein

Name: MMP-24 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS566050
Price: 1125 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS566050

Activation generates two molecular species. One species begins at the N-terminus with Tyr156 of full-length MMP-24, while the other species is two aa residues shorter and starts with Leu158. Both species extend to Ser351 of MMP-24 and contain an additional… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MMP-24, Active Protein

Full Product Name

MMP-24 (catalytic domain) (human), (recombinant) (His-tag)

Product Gene Name

MMP-24 active protein

Host

E Coli

Form/Format

Liquid. In 50mM TRIS-HCl, pH7.5, containing 150mM NaCl and 5mM CaCl2

Purity/Purification

>=90% (SDS-PAGE)

Concentration

0.2mg/ml (lot specific)

Preparation and Storage

For long term storage, store at -80 degree C
Shipping: Shipped on Dry Ice

Molecular Weight

73,231 Da

OMIM

604871

3D Structure

ModBase 3D Structure for Q9Y5R2

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Specific Activity

>=120mU/mg protein. One unit is defined as the amount of enzyme that hydrolyzes 1umol Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 per min. at 37 degree C, pH7.5

Dry Ice Shipment

Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for MMP-24 active protein

Cellular Analysis; Cell Organelles & Structures; Proteostasis; Proteolysis & Protein Degradation

Other Notes

Small volumes of MMP-24 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP-24 purchase

MBS566050 is an active protein targeting MMP-24. Also known as MMP-24 (catalytic domain) (human), (recombinant) (His-tag). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP-24. It may not necessarily be applicable to this product.

NCBI GI #

12585280

NCBI GeneID

10893

NCBI Accession #

Q9Y5R2.1

UniProt Primary Accession #

Q9Y5R2

UniProt Secondary Accession #

Q9H440; B7ZBG8

UniProt Related Accession #

Q9Y5R2

NCBI Official Full Name

Matrix metalloproteinase-24

NCBI Official Synonym Full Names

matrix metallopeptidase 24 (membrane-inserted)

NCBI Official Symbol

MMP24

NCBI Official Synonym Symbols

MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5

UniProt Protein Name

Matrix metalloproteinase-24

UniProt Synonym Protein Names

Membrane-type matrix metalloproteinase 5; MT-MMP 5; MTMMP5; Membrane-type-5 matrix metalloproteinase; MT5-MMP; MT5MMP

Protein Family

Matrix metalloproteinase

UniProt Gene Name

MMP24

UniProt Synonym Gene Names

MT5MMP; MMP-24; MT-MMP 5; MTMMP5; MT5-MMP; MT5MMP

UniProt Entry Name

MMP24_HUMAN

NCBI Protein Information

matrix metalloproteinase-24; membrane-type 5 matrix metalloproteinase; membrane-type matrix metalloproteinase 5; membrane-type-5 matrix metalloproteinase; matrix metalloproteinase 24 (membrane-inserted)

NCBI Summary for MMP-24

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]

UniProt Comments for MMP-24

MMP24: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. Belongs to the peptidase M10A family.

Protein type: Membrane protein, integral; EC 3.4.24.-; Activator; Protease

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: proteinaceous extracellular matrix; integral to plasma membrane; trans-Golgi network membrane

Molecular Function: zinc ion binding; cadherin binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding

Biological Process: positive regulation of catalytic activity; glial cell differentiation; proteolysis; detection of temperature stimulus involved in sensory perception of pain

Research Articles on MMP-24

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MMP-24 active protein

Reference Product	PubMed Publications
FURIN active protein	>2 publications with MMP-24 and FURIN
TIMP1 active protein	>2 publications with MMP-24 and TIMP1
TIMP2 active protein	>1 publications with MMP-24 and TIMP2

Pathways associated with MMP-24 active protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram

Diseases associated with MMP-24 active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>5 publications with MMP-24 and Nervous System Diseases
Disease Models, Animal Antibodies	>3 publications with MMP-24 and Disease Models, Animal
Inflammation Antibodies	>2 publications with MMP-24 and Inflammation
Skin Diseases Antibodies	>1 publications with MMP-24 and Skin Diseases
Gonadal Disorders Antibodies	>1 publications with MMP-24 and Gonadal Disorders
Lung Neoplasms Antibodies	>1 publications with MMP-24 and Lung Neoplasms
Hypertension Antibodies	>1 publications with MMP-24 and Hypertension
Atrophy Antibodies	>1 publications with MMP-24 and Atrophy
Proteinuria Antibodies	>1 publications with MMP-24 and Proteinuria
Prostatic Diseases Antibodies	>1 publications with MMP-24 and Prostatic Diseases

Organs/Tissues associated with MMP-24 active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>11 publications with MMP-24 and Brain
Kidney Antibodies	>4 publications with MMP-24 and Kidney
Nerve Antibodies	>3 publications with MMP-24 and Nerve
Embryonic Tissue Antibodies	>2 publications with MMP-24 and Embryonic Tissue
Testis Antibodies	>2 publications with MMP-24 and Testis
Skin Antibodies	>1 publications with MMP-24 and Skin
Pancreas Antibodies	>1 publications with MMP-24 and Pancreas
Eye Antibodies	>1 publications with MMP-24 and Eye
Blood Antibodies	>1 publications with MMP-24 and Blood
Muscle Antibodies	>1 publications with MMP-24 and Muscle