Matriptase-2 (TMPRSS6) Active Protein

Name: TMPRSS6 Active Protein; Matriptase-2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS566091
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS566091

Matriptase-2 (TMPRSS6) is a type II transmembrane serine protease mainly produced by the liver. It acts as a potent negative regulator of hepcidin, a hepatic peptide hormone and integral player in regulating iron homeostasis.Matriptase-2 plays an important… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Matriptase-2 (TMPRSS6), Active Protein

Full Product Name

Matriptase-2 (human), (recombinant) [Vial content: 500U]

Product Gene Name

TMPRSS6 active protein

Host

Drosophila Schneider 2 (S2) cells

Form/Format

Liquid. In 100mM TRIS-HCl, pH9.0, containing 150 mM sodium chloride and 20% glycerol

Purity/Purification

Purified by multi-step chromatography

Preparation and Storage

For long term storage, store at -80 degree C
Stable for at least 6 months when stored at -20 degree C. Recommended Assay Buffer: 100mM TRIS, pH9.0, containing 0.5mg/ml BSA. Do not store diluted solutions
Avoid freeze/thaw cycles
Shipping: Shipped on Blue Ice

Molecular Weight

91,333 Da

OMIM

AJ319876 mRNA

3D Structure

ModBase 3D Structure for Q8IU80

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Source Note

Recombinant human matriptase-2 (aa 78-811) is fused at the C-terminus to a V5-His-tag. Produced by plasmid transfection expression

Activity

>=2.5 U/ul

Biological Activity

Trypsin-like serine protease

Specific Activity

One U = 10 pmol/min, using Boc-Gln-Ala-Arg-AMC (50uM) as substrate at 37 degree C

Product Categories/Family for TMPRSS6 active protein

Proteostasis; Proteolysis & Protein Degradation

Other Notes

Small volumes of TMPRSS6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMPRSS6 purchase

MBS566091 is an active protein targeting TMPRSS6. Also known as Matriptase-2 (human), (recombinant) [Vial content: 500U]. Host: Drosophila Schneider 2 (S2) cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TMPRSS6. It may not necessarily be applicable to this product.

NCBI GI #

573014826

NCBI GeneID

164656

NCBI Accession #

NP_001275929.1

UniProt Primary Accession #

Q8IU80

UniProt Secondary Accession #

Q5TI06; Q6ICC2; Q6UXD8; Q8IUE2; Q8IXV8; B0QYB4; B0QYB7; B0QYB8

UniProt Related Accession #

Q8IU80

GenBank Nucleotide #

NM_001289000.1

NCBI Official Full Name

transmembrane protease serine 6 isoform 1

NCBI Official Synonym Full Names

transmembrane protease, serine 6

NCBI Official Symbol

TMPRSS6

NCBI Official Synonym Symbols

IRIDA

UniProt Protein Name

Transmembrane protease serine 6

UniProt Synonym Protein Names

Matriptase-2

Protein Family

Transmembrane protease serine

UniProt Gene Name

TMPRSS6

NCBI Protein Information

transmembrane protease serine 6

NCBI Summary for TMPRSS6

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

UniProt Comments for TMPRSS6

Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.

Research Articles on TMPRSS6

1. Matriptase-2 deficiency causes iron deficiency anemia during the early postnatal development, but not during fetal development in humans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TMPRSS6 active protein

Reference Product	PubMed Publications
HAMP active protein	>62 publications with TMPRSS6 and HAMP
HFE active protein	>37 publications with TMPRSS6 and HFE
TFR2 active protein	>14 publications with TMPRSS6 and TFR2
BMP6 active protein	>12 publications with TMPRSS6 and BMP6

Pathways associated with TMPRSS6 active protein

Products by Pathway	Pathway Diagram
Collagen Degradation Pathway antibodies	Collagen Degradation Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Hfe Effect On Hepcidin Production Pathway antibodies	Hfe Effect On Hepcidin Production Pathway Diagram

Diseases associated with TMPRSS6 active protein

Disease Name	Pubmed Publications
Anemia, Iron-Deficiency Antibodies	>92 publications with TMPRSS6 and Anemia, Iron-Deficiency
Iron-Refractory Iron Deficiency Anemia Antibodies	>41 publications with TMPRSS6 and Iron-Refractory Iron Deficiency Anemia
Inflammation Antibodies	>16 publications with TMPRSS6 and Inflammation
Disease Models, Animal Antibodies	>10 publications with TMPRSS6 and Disease Models, Animal
Liver Diseases Antibodies	>9 publications with TMPRSS6 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>4 publications with TMPRSS6 and Carcinoma, Hepatocellular
Fatty Liver Antibodies	>3 publications with TMPRSS6 and Fatty Liver
Kidney Diseases Antibodies	>2 publications with TMPRSS6 and Kidney Diseases
Necrosis Antibodies	>2 publications with TMPRSS6 and Necrosis
Liver Neoplasms Antibodies	>2 publications with TMPRSS6 and Liver Neoplasms

Organs/Tissues associated with TMPRSS6 active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>52 publications with TMPRSS6 and Liver
Brain Antibodies	>3 publications with TMPRSS6 and Brain
Lung Antibodies	>1 publications with TMPRSS6 and Lung