TARC Active Protein

Name: TARC Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS566092
Price: 575 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS566092

Thymus and activation regulated chemokine (TARC), also known as CCL17, is a chemokine produced by thymus tissue constitutively and activated PBMCs (mainly DCs). TARC signals through the CCR4 receptor to induce chemotaxis of Th2 cells. TARC is thought to be… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TARC, Active Protein

Full Product Name

TARC (human), (recombinant)

Product Gene Name

TARC active protein

Host

E Coli

Form/Format

White lyophilized (freeze-dried) powder. Lyophilized from 0.02% TFA. Sterile filtered

Purity/Purification

>=98% (HPLC, Reducing and Non-reducing SDS-PAGE, UV spectroscopy at 280 nm)

Preparation and Storage

For long term storage, store at -20 degree C
It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage
Centrifuge the vial before opening the cap. After reconstitution, prepare aliquots and store at -20 degree C

Molecular Weight

OMIM

601520

3D Structure

ModBase 3D Structure for Q92583

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Source Note

Non-glycosylated protein, containing 71 amino acids

Endotoxin

<=1EU/ug protein measured by kinetic LAL analysis

Biological Activity

The activity is determined by the ability to chemoattract human T cells which is typically observed at a concentration of 2-40ng/ml

Reconstitution

When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1mg/ml, which can be further diluted into other aqueous solutions

Product Categories/Family for TARC active protein

Cellular Analysis; Cell Growth & Development; Stem Cells

Other Notes

Small volumes of TARC active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TARC purchase

MBS566092 is an active protein targeting TARC. Also known as TARC (human), (recombinant). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TARC. It may not necessarily be applicable to this product.

NCBI GI #

3024711

NCBI GeneID

6361

NCBI Accession #

Q92583.1

UniProt Primary Accession #

Q92583

UniProt Secondary Accession #

Q2M287; A0N0Q9

UniProt Related Accession #

Q92583

NCBI Official Full Name

C-C motif chemokine 17

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 17

NCBI Official Symbol

CCL17

NCBI Official Synonym Symbols

TARC; ABCD-2; SCYA17; A-152E5.3

UniProt Protein Name

C-C motif chemokine 17

UniProt Synonym Protein Names

CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL17

UniProt Synonym Gene Names

SCYA17; TARC

UniProt Entry Name

CCL17_HUMAN

NCBI Protein Information

C-C motif chemokine 17; CC chemokine TARC; T cell-directed CC chemokine; small-inducible cytokine A17; thymus and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 17

NCBI Summary for TARC

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

UniProt Comments for TARC

CCL17: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR4 chemokine receptor binding; chemokine activity; receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; multicellular organismal development; immune response; negative regulation of myoblast differentiation; inflammatory response; chemotaxis

Research Articles on TARC

1. Although TARC and I-TAC may not directly regulate pruritus in atopic dermatitis patients, these chemokines are very sensitive disease markers of AD.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TARC active protein

Reference Product	PubMed Publications
CCR4 active protein	>246 publications with TARC and CCR4
CXCR3 active protein	>60 publications with TARC and CXCR3
CCR5 active protein	>36 publications with TARC and CCR5
CCR8 active protein	>34 publications with TARC and CCR8
CCR3 active protein	>32 publications with TARC and CCR3
CCR7 active protein	>23 publications with TARC and CCR7
CCR6 active protein	>20 publications with TARC and CCR6
STAT6 active protein	>20 publications with TARC and STAT6
CCR1 active protein	>16 publications with TARC and CCR1
CCR2 active protein	>12 publications with TARC and CCR2

Pathways associated with TARC active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram

Diseases associated with TARC active protein

Disease Name	Pubmed Publications
Hypersensitivity Antibodies	>288 publications with TARC and Hypersensitivity
Inflammation Antibodies	>270 publications with TARC and Inflammation
Respiratory Tract Diseases Antibodies	>182 publications with TARC and Respiratory Tract Diseases
Dermatitis, Atopic Antibodies	>166 publications with TARC and Dermatitis, Atopic
Lung Diseases Antibodies	>150 publications with TARC and Lung Diseases
Asthma Antibodies	>135 publications with TARC and Asthma
Respiratory Hypersensitivity Antibodies	>117 publications with TARC and Respiratory Hypersensitivity
Necrosis Antibodies	>101 publications with TARC and Necrosis
Disease Models, Animal Antibodies	>69 publications with TARC and Disease Models, Animal
Fibrosis Antibodies	>32 publications with TARC and Fibrosis

Organs/Tissues associated with TARC active protein

Organ/Tissue Name	Pubmed Publications
Mammary Gland Antibodies	>1 publications with TARC and Mammary Gland