Ltbetar (LTBR) Human Recombinant Protein

LTbetaR is a 75kDa type I transmembrane protein belonging to the TNF receptor family. It is 414 aa long and contains 4 cysteine-rich repeats in its extracellular domain. It is expressed on monocytes, fibroblasts, stromal and muscle cells. It is known to activate nuclear factor NF-kappaB, to interact with NIK and to induce cell death via TNF receptor-associated factor 3 (TRAF3). LTbetaR has two known ligands: LIGHT and LTalpha1beta2. It has been shown to be involved in splenic architecture development, lympHnode genesis and affinity maturation, as well as in the development of diabetes and colitis. It has been implicated in the induction of HIV replication and impairs prion replication in mice lacking follicular dendritic cells. Historical data has shown that LTbetaR inhibits human LIGHT- and LTalpha1beta2-mediated effects, such as cytotoxic effects, on HT29 target cells.

Small volumes of LTBR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS566216 is a recombinant protein targeting LTBR. Also known as LTbetaR (human):Fc (human), (recombinant). Reactive in Human, Mouse. Host: HEK293 cells.