Human FN14 Recombinant Protein – Cat# MBS566233

FN14 Human Recombinant Protein

Name: FN14 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS566233
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS566233

The fibroblast growth factor-inducible-14 (Fn14) is a 129 aa type Ia transmembrane protein. Fn14 is a growth-factor regulated, immediate-early response protein. It is expressed in a developmental and adult tissue-specific manner. Fn14 expression decreases… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Fn14, Recombinant Protein

Full Product Name

Fn14 (human):Fc (human), (recombinant)

Product Gene Name

Fn14 recombinant protein

Host

HEK293 cells

Species Reactivity

Human, Mouse

Form/Format

Lyophilized. Contains PBS

Purity/Purification

>=95% (SDS-PAGE)

Concentration

1mg/ml after reconstitution (lot specific)

Specificity

Binds human and mouse TWEAK

Preparation and Storage

Stable for at least six months after receipt when stored at -20 degree C
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 degree C
Shipping: Shipped on Blue Ice

Molecular Weight

10,191 Da

OMIM

605914

3D Structure

ModBase 3D Structure for Q9NP84

Source Note

The extracellular domain of human Fn14 (aa 1-75) is fused at the C-terminus to the Fc portion of human IgG1 and a linker peptide (2 aa)

Endotoxin

<0.1EU/ug (LAL test

Reconstitution

Reconstitute with 50ul sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein

Product Categories/Family for Fn14 recombinant protein

Cellular Analysis; Cell Signaling

Applications Tested/Suitable for Fn14 recombinant protein

ELISA (EIA)

Other Notes

Small volumes of Fn14 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Fn14 purchase

MBS566233 is a recombinant protein targeting Fn14. Also known as Fn14 (human):Fc (human), (recombinant). Reactive in Human, Mouse. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for Fn14. It may not necessarily be applicable to this product.

NCBI GI #

7706186

NCBI GeneID

51330

NCBI Accession #

NP_057723.1

UniProt Primary Accession #

Q9NP84

UniProt Secondary Accession #

Q9HCS0; D3DUA6

UniProt Related Accession #

Q9NP84

GenBank Nucleotide #

NM_016639.2

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 12A

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 12A

NCBI Official Symbol

TNFRSF12A

NCBI Official Synonym Symbols

FN14; CD266; TWEAKR

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 12A

UniProt Synonym Protein Names

Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266

UniProt Gene Name

TNFRSF12A

UniProt Synonym Gene Names

FN14; FGF-inducible 14; TweakR

UniProt Entry Name

TNR12_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 12A; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; tweak-receptor; type I transmembrane protein Fn14

UniProt Comments for Fn14

TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: substrate-bound cell migration, cell attachment to substrate; positive regulation of apoptosis; positive regulation of axon extension; angiogenesis; regulation of angiogenesis

Research Articles on Fn14

1. Results position TWEAK-Fn14 signaling through Mcl-1 as a significant mechanism for NSCLC tumor cell survival

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Fn14 recombinant protein

Reference Product	PubMed Publications
TNFSF12 recombinant protein	>5 publications with Fn14 and TNFSF12
TNFRSF25 recombinant protein	>1 publications with Fn14 and TNFRSF25

Pathways associated with Fn14 recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
TWEAK Signaling Pathway antibodies	TWEAK Signaling Pathway Diagram

Diseases associated with Fn14 recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>14 publications with Fn14 and Necrosis
Inflammation Antibodies	>9 publications with Fn14 and Inflammation
Neoplasms, Experimental Antibodies	>4 publications with Fn14 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>3 publications with Fn14 and Lung Neoplasms
Cardiovascular Diseases Antibodies	>3 publications with Fn14 and Cardiovascular Diseases
Adenocarcinoma Antibodies	>3 publications with Fn14 and Adenocarcinoma
Lung Diseases Antibodies	>3 publications with Fn14 and Lung Diseases
Heart Diseases Antibodies	>2 publications with Fn14 and Heart Diseases
Disease Models, Animal Antibodies	>2 publications with Fn14 and Disease Models, Animal
Breast Neoplasms Antibodies	>1 publications with Fn14 and Breast Neoplasms

Organs/Tissues associated with Fn14 recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>7 publications with Fn14 and Vascular
Lung Antibodies	>7 publications with Fn14 and Lung
Muscle Antibodies	>5 publications with Fn14 and Muscle
Blood Antibodies	>4 publications with Fn14 and Blood
Eye Antibodies	>3 publications with Fn14 and Eye
Kidney Antibodies	>2 publications with Fn14 and Kidney
Heart Antibodies	>2 publications with Fn14 and Heart
Bone Antibodies	>2 publications with Fn14 and Bone
Brain Antibodies	>1 publications with Fn14 and Brain
Intestine Antibodies	>1 publications with Fn14 and Intestine