DLC1 Antibody – Rat Monoclonal

LC8: a highly conserved cytoplasmic protein of the dynein light chain family. Cytoplasmic dyneins are large enzyme complexes. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain. Interacts with and inhibits the activity of neuronal nitric oxide synthase (nNOS). A highly conserved protein, showing 92% amino acid similarity with the nematode homolog. Binding of this protein destabilizes the nNOS dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.

Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 5|5 F

Cellular Component: centrosome; cytoplasm; cytoplasmic dynein complex; cytoskeleton; cytosol; kinetochore; membrane; nucleus; signalosome

Molecular Function: dynein intermediate chain binding; enzyme binding; enzyme inhibitor activity; nitric-oxide synthase regulator activity; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity

Biological Process: negative regulation of nitric oxide biosynthetic process; negative regulation of phosphorylation