PKA Alpha (PRKACA) Active Protein

This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013]

PKACA: catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described.

Protein type: Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.11; AGC group; PKA family

Cellular Component: Golgi apparatus; centrosome; neuron projection; protein complex; mitochondrion; cilium; cAMP-dependent protein kinase complex; cell projection; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleus; neuromuscular junction; AMP-activated protein kinase complex

Molecular Function: cAMP-dependent protein kinase activity; nucleotide binding; protein kinase binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; protein complex binding; kinase activity; ATP binding; Rab GTPase binding

Biological Process: regulation of synaptic transmission; regulation of synaptic transmission, glutamatergic; regulation of osteoblast differentiation; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; negative regulation of meiotic cell cycle; protein amino acid phosphorylation; regulation of cellular respiration; positive regulation of protein export from nucleus; peptidyl-serine phosphorylation; mesoderm formation; neural tube closure; positive regulation of cell proliferation; phosphorylation; sperm capacitation