PRL-1 Active Protein

Name: PRL-1 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS566697
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS566697

PRL phosphatases comprise a class of small oncogenic phosphatases that are prenylated at their carboxyl-termini. PRL-1 is overexpressed during cell proliferation in the liver and during differentiation of epithelial cells in the digestive tract. It augments… More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PRL-1, Active Protein

Full Product Name

PRL-1 (human), (recombinant) (His-tag)

Product Gene Name

PRL-1 active protein

Host

E Coli

Form/Format

Liquid. In 40mM TRIS-HCl, pH8.0, containing 110mM sodium chloride, potassium chloride, 200mM imidazole, 20% glycerol and 3mM DTT

Purity/Purification

>=75% (SDS-PAGE)

Preparation and Storage

For long term storage, store at -80 degree C
Dilution of the enzyme followed by refreezing may lead to loss of activity
Shipping: Shipped on Dry Ice

Molecular Weight

19,815 Da

OMIM

601585

3D Structure

ModBase 3D Structure for Q93096

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Source Note

The catalytic domain of PRL-1 (aa 2-173) is fused at the N-terminus to a His-tag

Specific Activity

>=0.168U/min/ug. One unit will hydrolyze 1pmol para-nitrophenyl phosphate (PNPP) per minute at 37 degree C. Assay buffer: 50mM TRIS, pH7.4, containing 150mM sodium chloride, 5mM dithiothreitol and 12.5mM PNPP

Dry Ice Shipment

Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for PRL-1 active protein

Proteostasis; Posttranslational Modifications

Other Notes

Small volumes of PRL-1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRL-1 purchase

MBS566697 is an active protein targeting PRL-1. Also known as PRL-1 (human), (recombinant) (His-tag). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PRL-1. It may not necessarily be applicable to this product.

NCBI GI #

4506283

NCBI GeneID

7803

NCBI Accession #

NP_003454.1

UniProt Primary Accession #

Q93096

UniProt Secondary Accession #

O00648; Q49A54; B2R6C8

UniProt Related Accession #

Q93096

GenBank Nucleotide #

NM_003463.4

NCBI Official Full Name

protein tyrosine phosphatase type IVA 1

NCBI Official Synonym Full Names

protein tyrosine phosphatase type IVA, member 1

NCBI Official Symbol

PTP4A1

NCBI Official Synonym Symbols

HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)

UniProt Protein Name

Protein tyrosine phosphatase type IVA 1

UniProt Synonym Protein Names

PTP(CAAXI); Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PRL-1

Protein Family

Protein tyrosine phosphatase

UniProt Gene Name

PTP4A1

UniProt Synonym Gene Names

PRL1; PTPCAAX1; PRL-1

UniProt Entry Name

TP4A1_HUMAN

NCBI Protein Information

protein tyrosine phosphatase type IVA 1; protein tyrosine phosphatase type IVA protein 1; protein-tyrosine phosphatase 4a1; protein-tyrosine phosphatase of regenerating liver 1

NCBI Summary for PRL-1

This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

UniProt Comments for PRL-1

PTP4A1: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. Belongs to the protein-tyrosine phosphatase family.

Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q12

Cellular Component: internal side of plasma membrane; endoplasmic reticulum; early endosome; cytoplasm; spindle

Molecular Function: protein tyrosine phosphatase activity

Biological Process: multicellular organismal development; cell cycle; positive regulation of cell migration

Research Articles on PRL-1

1. PTP4A1-PHF3-EYS variants were associated with alcohol dependence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRL-1 active protein

Reference Product	PubMed Publications
PTP4A2 active protein	>18 publications with PRL-1 and PTP4A2
SRC active protein	>4 publications with PRL-1 and SRC
EGR1 active protein	>3 publications with PRL-1 and EGR1
ATF7 active protein	>1 publications with PRL-1 and ATF7
RAC1 active protein	>1 publications with PRL-1 and RAC1

Pathways associated with PRL-1 active protein

Products by Pathway	Pathway Diagram
Signaling Events Mediated By PRL Pathway antibodies	Signaling Events Mediated By PRL Pathway Diagram

Diseases associated with PRL-1 active protein

Disease Name	Pubmed Publications
Liver Neoplasms Antibodies	>17 publications with PRL-1 and Liver Neoplasms
Adenocarcinoma Antibodies	>7 publications with PRL-1 and Adenocarcinoma
Liver Diseases Antibodies	>6 publications with PRL-1 and Liver Diseases
Lung Neoplasms Antibodies	>5 publications with PRL-1 and Lung Neoplasms
Lung Diseases Antibodies	>5 publications with PRL-1 and Lung Diseases
Neoplasms, Experimental Antibodies	>4 publications with PRL-1 and Neoplasms, Experimental
Breast Neoplasms Antibodies	>4 publications with PRL-1 and Breast Neoplasms
Cell Transformation, Neoplastic Antibodies	>4 publications with PRL-1 and Cell Transformation, Neoplastic
Carcinoma, Hepatocellular Antibodies	>3 publications with PRL-1 and Carcinoma, Hepatocellular
Disease Models, Animal Antibodies	>3 publications with PRL-1 and Disease Models, Animal

Organs/Tissues associated with PRL-1 active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>39 publications with PRL-1 and Liver
Lung Antibodies	>7 publications with PRL-1 and Lung
Intestine Antibodies	>7 publications with PRL-1 and Intestine
Lymph Antibodies	>5 publications with PRL-1 and Lymph
Lymph Node Antibodies	>5 publications with PRL-1 and Lymph Node
Eye Antibodies	>5 publications with PRL-1 and Eye
Ovary Antibodies	>4 publications with PRL-1 and Ovary
Muscle Antibodies	>3 publications with PRL-1 and Muscle
Heart Antibodies	>3 publications with PRL-1 and Heart
Prostate Antibodies	>2 publications with PRL-1 and Prostate