HDAC10 Active Protein

Name: HDAC10 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS566698
Price: 955 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS566698

HDAC10 is ubiquitously expressed in human tissues and many cell lines. Its domain structure resembles that of its closest homolog and fellow class IIb HDAC, HDAC6, but rather than two active deacetylase domains, it has one active domain (N-terminal) and a… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

HDAC10, Active Protein

Full Product Name

HDAC10 (human), (recombinant) (His-tag)

Product Gene Name

HDAC10 active protein

Host

Sf9 Insect cells

Form/Format

Liquid. In 50mM TRIS, pH8.0, containing 138mM NaCl and 10% glycerol

Purity/Purification

Partially purified by single-step affinity chromatography and gel filtration

Preparation and Storage

For long term storage, store at -80 degree C
Shipping: Shipped on Dry Ice

Molecular Weight

~71 kDa

OMIM

608544

3D Structure

ModBase 3D Structure for Q969S8

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Source Note

Produced in a baculovirus expression system

Biological Activity

Hydrolysis of N-epsilon-acetyl-lysine residues of histones

Specific Activity

>=2U/ug. One unit is defined as the amount of enzyme that deacetylates 1 pmol/min of FLUOR DE LYS-SIRT1 substrate at 37 degree C / 500uM

Product Categories/Family for HDAC10 active protein

Cellular Analysis; Cell Death; Stem Cells; Epigenetics; Histone Posttranslational Modifications; Proteostasis; Posttranslational Modifications; Proteolysis & Protein Degradation

Other Notes

Small volumes of HDAC10 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDAC10 purchase

MBS566698 is an active protein targeting HDAC10. Also known as HDAC10 (human), (recombinant) (His-tag). Host: Sf9 Insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for HDAC10. It may not necessarily be applicable to this product.

NCBI Accession #

NM_032019

UniProt Primary Accession #

Q969S8

UniProt Protein Name

Histone deacetylase 10

Protein Family

Histone deacetylase

UniProt Gene Name

HDAC10

UniProt Synonym Gene Names

HD10

UniProt Entry Name

HDA10_HUMAN

UniProt Comments for HDAC10

HDAC10: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Belongs to the histone deacetylase family. HD type 2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Deacetylase; EC 3.5.1.98; Transcription factor

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: nucleoplasm; histone deacetylase complex; cytoplasm; nucleus

Molecular Function: protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); histone deacetylase binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity

Biological Process: Notch signaling pathway; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; protein amino acid deacetylation; regulation of transcription, DNA-dependent; histone deacetylation; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; oligodendrocyte development; negative regulation of transcription, DNA-dependent

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.