SENP1 Active Protein

Name: SENP1 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS566743
Price: 615 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS566743

SENP1 fragment has been reported to co-localize with a herpes virus protein ICP0 during early infection. This co-localization may be involved in the ICP0-induced loss of SUMO-1-modified PML in infected cells. Characterization of the localization and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

SENP1, Active Protein

Full Product Name

SENP1 (Catalytic Domain) (human), (recombinant) (GST)

Product Gene Name

SENP1 active protein

Host

E Coli

Form/Format

Liquid. In 50mM Tris, 150mM NaCl, pH7.5, containing 0.5mM DTT

Preparation and Storage

For long term storage, store at -80 degree C
Shipping: Shipped on Dry Ice

Molecular Weight

73,481 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (48436681..48500091, complement). Location: 12q13.1

OMIM

612157

3D Structure

ModBase 3D Structure for Q9P0U3

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

This fragment has full de-SUMOylating activity

Product Categories/Family for SENP1 active protein

Cellular Analysis; Stem Cells; Proteostasis; Protein Synthesis & Folding; Posttranslational Modifications; Ubiquitin & UBL Signaling

Other Notes

Small volumes of SENP1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SENP1 purchase

MBS566743 is an active protein targeting SENP1. Also known as SENP1 (Catalytic Domain) (human), (recombinant) (GST). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SENP1. It may not necessarily be applicable to this product.

NCBI GI #

390131988

NCBI GeneID

29843

NCBI Accession #

NP_001254523.1

UniProt Primary Accession #

Q9P0U3

UniProt Secondary Accession #

Q86XC8; A8K7P5

UniProt Related Accession #

Q9P0U3

GenBank Nucleotide #

NM_001267594.1

NCBI Official Full Name

sentrin-specific protease 1

NCBI Official Synonym Full Names

SUMO1/sentrin specific peptidase 1

NCBI Official Symbol

SENP1

NCBI Official Synonym Symbols

SuPr-2

UniProt Protein Name

Sentrin-specific protease 1

UniProt Synonym Protein Names

Sentrin/SUMO-specific protease SENP1

Protein Family

Sentrin-specific protease

UniProt Gene Name

SENP1

UniProt Entry Name

SENP1_HUMAN

NCBI Protein Information

sentrin-specific protease 1; SUMO1/sentrin specific protease 1; sentrin/SUMO-specific protease SENP1

NCBI Summary for SENP1

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

UniProt Comments for SENP1

SENP1: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Protease; EC 3.4.22.68

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: nucleoplasm; nuclear membrane; focal adhesion; cytoplasm; nucleus

Molecular Function: protein binding; endopeptidase activity; SUMO-specific protease activity

Biological Process: caspase activation; protein desumoylation; cellular protein metabolic process; protein sumoylation; positive regulation of transcription from RNA polymerase II promoter; proteolysis; post-translational protein modification; negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Research Articles on SENP1

1. Data show that the loss of OCT4 expression under hypoxia can be triggered by sumoylation, which was regulated by the SUMO1 peptidase SENP1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SENP1 active protein

Reference Product	PubMed Publications
HDAC1 active protein	>1 publications with SENP1 and HDAC1

Pathways associated with SENP1 active protein

Products by Pathway	Pathway Diagram
Regulation Of Androgen Receptor Activity Pathway antibodies	Regulation Of Androgen Receptor Activity Pathway Diagram

Diseases associated with SENP1 active protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>5 publications with SENP1 and Cardiovascular Diseases
Anemia Antibodies	>2 publications with SENP1 and Anemia
Hypertension Antibodies	>2 publications with SENP1 and Hypertension
Hypertrophy Antibodies	>1 publications with SENP1 and Hypertrophy
Nervous System Diseases Antibodies	>1 publications with SENP1 and Nervous System Diseases
Weight Loss Antibodies	>1 publications with SENP1 and Weight Loss
Embryo Loss Antibodies	>1 publications with SENP1 and Embryo Loss
Necrosis Antibodies	>1 publications with SENP1 and Necrosis