Globo H Antibody – Mouse Monoclonal

Globo H is a hexasaccharide formed from the pentasaccharide precursor, SSEA3 (stage-specific embryonic antigen 3). It is a member of a family of antigenic carbohydrates expressed on the surface of cancer cells as glycolipids and possibly glycoproteins. Globo H is overexpressed on many carcinomas, such as breast, colon, ovarian, gastric, pancreatic, lung, and prostate. Expression of Globo H in carcinomas include more than half of all ductal, lobular, and tubular breast carcinomas, but not in non-epithelial breast tumors. Cancer stem cells and human embryonic stem cells also express global H, although expression decreases when cells are differentiated toward both neural progenitor cells and to a lesser extent in endodermal lineage cells. Expression in normal tissues is limited to cells composing secretory borders. Globo H is considered a target for immunotherapy of many epithelial cancers.

Small volumes of anti-Globo H antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS566876 is an antibody targeting Globo H. Also known as Globo H (human) monoclonal antibody (VK9). Reactive in Human. Host: Mouse.