DEFB103B Recombinant Protein – Cat# MBS567208

Beta-Defensin 3 (DEFB103B) Recombinant Protein

Name: DEFB103B Recombinant Protein; Beta-Defensin 3; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS567208
Price: 500 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS567208

beta-Defensin 3 (BD-3) is a member of the defensin class of antimicrobial peptides that exert host defense responses against bacteria, fungi and viruses through microbial membranes. Interferon-gamma stimulates BD-3 expression and is important during… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Beta-Defensin 3 (DEFB103B), Recombinant Protein

Full Product Name

Beta-Defensin 3 (human), (recombinant)

Product Gene Name

DEFB103B recombinant protein

Sequence

GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK

Host

E Coli

Form/Format

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% trifluoroacetic acid (TFA)

Purity/Purification

>=95% (SDS-PAGE)

Preparation and Storage

For long term storage, store at -80 degree C
Reconstituted solution is stable for 3 months when stored at -20 degree C to -80 degree C and for 1 month when stored at 4 degree C after reconstituting as directed
Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution and allow several minutes for complete reconstitution. Do not vortex. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution and store at -80 degree C. Avoid freeze/thaw cycles

Molecular Weight

7,697 Da

OMIM

606611

3D Structure

ModBase 3D Structure for P81534

Endotoxin

<=1EU/ug (LAL)

Reconstitution

Reconstitute with sterile 10 mM acetic acid at 0.1mg/mL

Product Categories/Family for DEFB103B recombinant protein

Cellular Analysis; Cell Signaling; Small Molecule Chemistry; Antimicrobial Peptides

Other Notes

Small volumes of DEFB103B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DEFB103B purchase

MBS567208 is a recombinant protein targeting DEFB103B. Also known as Beta-Defensin 3 (human), (recombinant). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DEFB103B. It may not necessarily be applicable to this product.

NCBI GI #

8923890

NCBI GeneID

55894

NCBI Accession #

NP_061131.1

UniProt Primary Accession #

P81534

UniProt Secondary Accession #

Q8NFG6; Q9NPF6

UniProt Related Accession #

P81534

GenBank Nucleotide #

NM_018661.4

NCBI Official Full Name

beta-defensin 103

NCBI Official Synonym Full Names

defensin, beta 103B

NCBI Official Symbol

DEFB103B

NCBI Official Synonym Symbols

BD-3; HBD3; HBP3; DEFB3; HBD-3; HBP-3; DEFB-3; DEFB103

UniProt Protein Name

Beta-defensin 103

UniProt Synonym Protein Names

Beta-defensin 3; BD-3; DEFB-3; HBD3; hBD-3; Defensin, beta 103; Defensin-like protein

Protein Family

Beta-defensin

UniProt Gene Name

DEFB103A

UniProt Synonym Gene Names

BD3; DEFB103; DEFB3; BD-3; DEFB-3; HBD3; hBD-3

UniProt Entry Name

D103A_HUMAN

NCBI Protein Information

beta-defensin 103; beta-defensin 3; defensin, beta 103; defensin-like protein

NCBI Summary for DEFB103B

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense. [provided by RefSeq, Jul 2008]

UniProt Comments for DEFB103B

defensin, beta 3: Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. Belongs to the beta-defensin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: Golgi lumen; extracellular region

Biological Process: defense response to bacterium; innate immune response; positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

Research Articles on DEFB103B

1. Data show that Lactobacillus crispatus promotes epithelial cell defense against Candida albicans infection through the involvement of TLR2/4, IL-8 and human beta-defensin 2 and 3, suggesting this Lactobacillus as an anti-infective agent against C. albicans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with DEFB103B recombinant protein

Products by Pathway	Pathway Diagram
Beta Defensins Pathway antibodies	Beta Defensins Pathway Diagram
Defensins Pathway antibodies	Defensins Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram