Growth and Differentiation Factor-11 (GDF11) Active Protein

Name: GDF11 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS567236
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS567236

Growth differentiation factor 11 (GDF-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Growth and Differentiation factor-11 (GDF11), Active Protein

Full Product Name

Growth and Differentiation factor-11 (human), (recombinant)

Product Gene Name

GDF11 active protein

Host

E Coli

Form/Format

Lyophilized from a sterile (0.2 micron) filtered solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity/Purification

>=95% (SDS-PAGE)

Preparation and Storage

For long term storage, store at -80 degree C
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80 degree C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution

Molecular Weight

45,091 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (56137064..56146665). Location: 12q13.2

OMIM

603936

3D Structure

ModBase 3D Structure for O95390

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Amino Acids

Contains 109/218 amino acids

Endotoxin

<=1EU/ug protein (LAL test)

Biological Activity

Alkaline phosphatase activity in ATDC5 cells; ED50 <= 100 ng/mL (>= 1.0 x 104 units/mg)

Reconstitution

Reconstitute in sterile 10mM HCl at 0.1mg/mL

Product Categories/Family for GDF11 active protein

Cellular Analysis; Cell Growth & Development

Other Notes

Small volumes of GDF11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDF11 purchase

MBS567236 is an active protein targeting GDF11. Also known as Growth and Differentiation factor-11 (human), (recombinant). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF11. It may not necessarily be applicable to this product.

NCBI GI #

5031613

NCBI GeneID

10220

NCBI Accession #

NP_005802.1

UniProt Primary Accession #

O95390

UniProt Secondary Accession #

Q9UID1; Q9UID2

UniProt Related Accession #

O95390

GenBank Nucleotide #

NM_005811.3

NCBI Official Full Name

growth/differentiation factor 11

NCBI Official Synonym Full Names

growth differentiation factor 11

NCBI Official Symbol

GDF11

NCBI Official Synonym Symbols

BMP11; BMP-11

UniProt Protein Name

Growth/differentiation factor 11

UniProt Synonym Protein Names

Bone morphogenetic protein 11

Protein Family

Growth/differentiation factor

UniProt Gene Name

GDF11

UniProt Synonym Gene Names

BMP11; GDF-11; BMP-11

UniProt Entry Name

GDF11_HUMAN

NCBI Protein Information

growth/differentiation factor 11; GDF-11; bone morphogenetic protein 11

NCBI Summary for GDF11

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]

UniProt Comments for GDF11

GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; metanephros development; skeletal development; cell development; growth

Research Articles on GDF11

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GDF11 active protein

Reference Product	PubMed Publications
PCSK5 active protein	>3 publications with GDF11 and PCSK5
WFIKKN1 active protein	>3 publications with GDF11 and WFIKKN1
ACVR2B active protein	>3 publications with GDF11 and ACVR2B
WIF1 active protein	>1 publications with GDF11 and WIF1
CDKN1A active protein	>1 publications with GDF11 and CDKN1A
MAFA active protein	>1 publications with GDF11 and MAFA
FOXG1 active protein	>1 publications with GDF11 and FOXG1
ACVR1B active protein	>1 publications with GDF11 and ACVR1B
ATOH7 active protein	>1 publications with GDF11 and ATOH7

Diseases associated with GDF11 active protein

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>7 publications with GDF11 and Congenital Abnormalities
Kidney Diseases Antibodies	>3 publications with GDF11 and Kidney Diseases
Disease Models, Animal Antibodies	>2 publications with GDF11 and Disease Models, Animal
Insulin Resistance Antibodies	>1 publications with GDF11 and Insulin Resistance
Neoplasm Metastasis Antibodies	>1 publications with GDF11 and Neoplasm Metastasis
Fatty Liver Antibodies	>1 publications with GDF11 and Fatty Liver
Urogenital Abnormalities Antibodies	>1 publications with GDF11 and Urogenital Abnormalities
Necrosis Antibodies	>1 publications with GDF11 and Necrosis

Organs/Tissues associated with GDF11 active protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>60 publications with GDF11 and Bone
Muscle Antibodies	>20 publications with GDF11 and Muscle
Embryonic Tissue Antibodies	>16 publications with GDF11 and Embryonic Tissue
Nerve Antibodies	>11 publications with GDF11 and Nerve
Kidney Antibodies	>8 publications with GDF11 and Kidney
Heart Antibodies	>6 publications with GDF11 and Heart
Eye Antibodies	>6 publications with GDF11 and Eye
Blood Antibodies	>5 publications with GDF11 and Blood
Mouth Antibodies	>5 publications with GDF11 and Mouth
Pancreas Antibodies	>5 publications with GDF11 and Pancreas