GRO-beta Recombinant Protein

Name: GRO-beta Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS567237
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS567237

Growth regulated protein beta (GRO-beta), also known as CXCL2, is a chemokine that is secreted by macrophages, neutrophils, and monocytes. GRO-beta functions as a chemoattractant for leukocytes and hematopoietic stem cells. GRO-beta activity is mediated… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GRO-beta, Recombinant Protein

Full Product Name

GRO-beta (human), (recombinant)

Product Gene Name

GRO-beta recombinant protein

Host

E Coli

Form/Format

Lyophilized from a sterile (0.2 micron) filtered solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity/Purification

>=95% (SDS-PAGE)

Preparation and Storage

For long term storage, store at -80 degree C
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80 degree C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution

Molecular Weight

11,389 Da

OMIM

139110

3D Structure

ModBase 3D Structure for P19875

Amino Acids

Contains 73 amino acids

Endotoxin

<=1EU/ug protein (LAL test)

Reconstitution

Reconstitute in sterile water at 0.1mg/mL

Product Categories/Family for GRO-beta recombinant protein

Cellular Analysis; Cell Signaling

Other Notes

Small volumes of GRO-beta recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRO-beta purchase

MBS567237 is a recombinant protein targeting GRO-beta. Also known as GRO-beta (human), (recombinant). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GRO-beta. It may not necessarily be applicable to this product.

NCBI GI #

2905630

NCBI GeneID

2920

NCBI Accession #

AAC03540.1

UniProt Primary Accession #

P19875

UniProt Secondary Accession #

Q6FGD6; Q9UPB8

UniProt Related Accession #

P19875

NCBI Official Full Name

macrophage inflammatory protein 2 alpha, partial

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 2

NCBI Official Symbol

CXCL2

NCBI Official Synonym Symbols

GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a

UniProt Protein Name

C-X-C motif chemokine 2

UniProt Synonym Protein Names

Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alphaCleaved into the following chain:GRO-beta(5-73); Alternative name(s):; GRO-beta-T; Hematopoietic synergistic factor; HSF; SB-251353

Protein Family

Growth-regulated protein

UniProt Gene Name

CXCL2

UniProt Synonym Gene Names

GRO2; GROB; MIP2A; SCYB2; Gro-beta; MIP2-alpha; HSF

UniProt Entry Name

CXCL2_HUMAN

NCBI Protein Information

C-X-C motif chemokine 2; gro-beta; MGSA beta; MIP2-alpha; GRO2 oncogene; growth-regulated protein beta; macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta

NCBI Summary for GRO-beta

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]

UniProt Comments for GRO-beta

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; response to molecule of bacterial origin; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; chemotaxis; inflammatory response; regulation of cell proliferation

Research Articles on GRO-beta

1. Simultaneous targeting of hCAP-G2 and MIP-2A is a promising strategy for the development of antitumor drugs as a treatment for intractable tumours.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRO-beta recombinant protein

Reference Product	PubMed Publications
CXCL1 recombinant protein	>541 publications with GRO-beta and CXCL1
CCL4 recombinant protein	>185 publications with GRO-beta and CCL4
CXCR2 recombinant protein	>147 publications with GRO-beta and CXCR2
CCL5 recombinant protein	>118 publications with GRO-beta and CCL5
CXCL3 recombinant protein	>98 publications with GRO-beta and CXCL3
CCL20 recombinant protein	>73 publications with GRO-beta and CCL20
CCR1 recombinant protein	>25 publications with GRO-beta and CCR1
CXCR1 recombinant protein	>24 publications with GRO-beta and CXCR1
CCR5 recombinant protein	>22 publications with GRO-beta and CCR5
CCL19 recombinant protein	>7 publications with GRO-beta and CCL19

Pathways associated with GRO-beta recombinant protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with GRO-beta recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>982 publications with GRO-beta and Inflammation
Necrosis Antibodies	>632 publications with GRO-beta and Necrosis
Lung Diseases Antibodies	>382 publications with GRO-beta and Lung Diseases
Disease Models, Animal Antibodies	>344 publications with GRO-beta and Disease Models, Animal
Lung Injury Antibodies	>257 publications with GRO-beta and Lung Injury
Pneumonia Antibodies	>172 publications with GRO-beta and Pneumonia
Reperfusion Injury Antibodies	>115 publications with GRO-beta and Reperfusion Injury
Neoplasms Antibodies	>114 publications with GRO-beta and Neoplasms
Wounds and Injuries Antibodies	>93 publications with GRO-beta and Wounds and Injuries
Edema Antibodies	>91 publications with GRO-beta and Edema

Organs/Tissues associated with GRO-beta recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1043 publications with GRO-beta and Blood
Lung Antibodies	>618 publications with GRO-beta and Lung
Liver Antibodies	>199 publications with GRO-beta and Liver
Bone Antibodies	>161 publications with GRO-beta and Bone
Bone Marrow Antibodies	>133 publications with GRO-beta and Bone Marrow
Brain Antibodies	>115 publications with GRO-beta and Brain
Intestine Antibodies	>110 publications with GRO-beta and Intestine
Kidney Antibodies	>97 publications with GRO-beta and Kidney
Eye Antibodies	>54 publications with GRO-beta and Eye
Lymph Node Antibodies	>41 publications with GRO-beta and Lymph Node