Cytokeratin 7 / Keratin K7 Antibody – Mouse Monoclonal

CytokeRatins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in Human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual Human cytokeRatins are numbered 1 to 20. The various epithelia in the Human body usually express cytokeRatins which are not only characteristic of the type of epithelium, but also related to the degree of matuRation or differentiation within an epithelium. CytokeRatin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeRatin antibodies are not only of assistance in the differential identification of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Ramaekers, F., van Niekerk, C., Poels, L., Schaafsma, E., Huijsmans, A., Robben, H., Schaart, G., and Vooijs, P. (1990). Use of monoclonal antibodies to keRatin 7 in the differential diagnosis of adenocarcinomas, Am J Pathol 136, 641-55. van Niekerk, C. C., Jap, P. H., Ramaekers, F. C., van de Molengraft, F., and Poels, L. G. (1991). Immunohistochemical demonstRation of keRatin 7 in routinely fixed paraffin-embedded Human tissues, J Pathol 165, 145-52. van Niekerk, C. C., Boerman, O. C., Ramaekers, F. C., and Poels, L. G. (1991). Marker profile of different phases in the transition of normal Human ovarian epithelium to ovarian carcinomas, Am J Pathol 138, 455-63. van de Molengraft, F. J., van Niekerk, C. C., Jap, P. H., and Poels, L. G. (1993). OV-TL 12/30 (keRatin 7 antibody) is a marker of glandular differentiation in lung cancer, Histopathology 22, 35-8. van Niekerk, C. C., Vooijs, P., Casparie-van Velsen, I. J., and Poels, L. G. (1997). Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies, Cancer Detect Prev 21, 247-57. Torenbeek, R., Lagendijk, J. H., Van Diest, P. J., Bril, H., van de Molengraft, F. J., and Meijer, C. J. (1998). Value of a panel of antibodies to identify the primary origin of adenocarcinomas presenting as bladder carcinoma, Histopathology 32, 20-7.

Small volumes of anti-CytokeRatin 7 / KeRatin K7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570002 is an antibody targeting CytokeRatin 7 / KeRatin K7. Also known as Mouse anti CytokeRatin 7 / KeRatin K7. Reactive in Human. Host: Mouse.