K-Cadherin/Cadherin-6 (CDH6) Antibody – Mouse Monoclonal

Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the Catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived.

Shimazui, T., Oosterwijk, E., Akaza, H., Bringuier, P., Ruijter, E., van Berkel, H., Wakka, J. O., van Bokhoven, A., Debruyne, F. M., and Schalken, J. A. (1998). Expression of cadherin-6 as a novel diagnostic tool to predict prognosis of patients with E-cadherin-absent renal cell carcinoma, Clin Cancer Res 4, 2419-24. Shimazui, T., Oosterwijk-Wakka, J., Akaza, H., Bringuier, P. P., Ruijter, E., Debruyne, F. M., Schalken, J. A., and Oosterwijk, E. (2000). AlteRations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma, Eur Urol 38, 331-8.

Small volumes of anti-CDH6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570007 is an antibody targeting CDH6. Also known as Mouse anti K-Cadherin/Cadherin-6. Reactive in Human, Rat. Host: Mouse.