Mouse Anti-CTNNA3 Monoclonal Antibody – Cat# MBS570076

Figure 1: Immunohistochemistry on paraffin section of human heart

Alphat- Catenin (CTNNA3) Antibody – Mouse Monoclonal

Name: CTNNA3 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS570076
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS570076

Catenins are proteins that connect cadherin/beta-Catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alphaT-Catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical… More details

$605 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

alphaT- Catenin (CTNNA3), Monoclonal Antibody

Full Product Name

Mouse anti alphaT- Catenin

Product Gene Name

anti-CTNNA3 antibody

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

892_24D2S

Host

Mouse

Species Reactivity

Human

Form/Format

The vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.

Specificity

892_24D2S reacts with an epitope loCated between residues 164-177 of the Human alphaT-Catenin protein.

Preparation and Storage

Store at 4 degree C, or in small aliquots at -20 degree C.

Molecular Weight

99,809 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (67672276..69455949, complement). Location: 10q22.2

OMIM

607667

3D Structure

ModBase 3D Structure for Q9UI47

Source Note

892_24D2S is a Mouse monoclonal IgG2a antibody derived by fusion of SP2/0-Ag14 Mouse myeloma cells with spleen cells from a C57Bl/6 Mouse immunized with a synthetic peptide corresponding to amino acids 164-177 of the Human alphaT-Catenin protein including an additional N-terminal cysteine (CVANKSDLQKTYQKL) coupled to keyhole limpet hemocyanin.

Product Categories/Family for anti-CTNNA3 antibody

Cell adhesion; Cardiovascular; Cell adhesion

Applications Tested/Suitable for anti-CTNNA3 antibody

Flow Cytometry (FC), Immunocytochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Application Notes for anti-CTNNA3 antibody

892_24D2S is suitable for immunofluorescence (aceton-fixed cells), immunocytochemistry (methanol and paraformaldehyde-fixed cells, followed by permeabilisation in 0.2% Triton-X 100 for 2 min), immunoprecipitation and immunoblotting. Optimal antibody dilution should be determined by titRation; recommended range is 1:25 - 1:50 for immunohistochemistry with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting appliCations.

Product References and Citations for anti-CTNNA3 antibody

Janssens, B., Goossens, S., Staes, K., Gilbert, B., van Hengel, J., Colpaert, C., Bruyneel, E., Mareel, M., and van Roy, F. (2001). alphaT-Catenin: a novel tissue-specific beta-Catenin-binding protein mediating strong cell-cell adhesion, J. Cell. Sci. 114, 3177-88.

Other Notes

Small volumes of anti-CTNNA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTNNA3 purchase

MBS570076 is an antibody targeting CTNNA3. Also known as Mouse anti alphaT- Catenin. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CTNNA3. It may not necessarily be applicable to this product.

NCBI GI #

6650345

NCBI GeneID

29119

NCBI Accession #

AAF21801.1

UniProt Primary Accession #

Q9UI47

UniProt Secondary Accession #

Q5VSR2; Q6P056

UniProt Related Accession #

Q9UI47

NCBI Official Full Name

alphaT-catenin

NCBI Official Synonym Full Names

catenin (cadherin-associated protein), alpha 3

NCBI Official Symbol

CTNNA3

NCBI Official Synonym Symbols

VR22

UniProt Protein Name

Catenin alpha-3

UniProt Synonym Protein Names

Alpha T-catenin; Cadherin-associated protein

Protein Family

Catenin

UniProt Gene Name

CTNNA3

UniProt Entry Name

CTNA3_HUMAN

NCBI Protein Information

catenin alpha-3; alpha T-catenin; alpha-T-catenin; alpha-catenin-like protein; cadherin-associated protein

NCBI Summary for CTNNA3

This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

UniProt Comments for CTNNA3

CTNNA3: May be involved in formation of stretch-resistant cell- cell adhesion complexes. Belongs to the vinculin/alpha-catenin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: cytoskeleton; lamellipodium; cytoplasm; fascia adherens

Molecular Function: actin filament binding; protein binding; cadherin binding

Biological Process: cell-cell adhesion

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 13

Research Articles on CTNNA3

1. Results suggest a causal relationship between CTNNA3 mutations and arrhythmogenic right ventricular cardiomyopathy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CTNNA3 antibody

Reference Product	PubMed Publications
CTNNB1 antibody	>11 publications with CTNNA3 and CTNNB1

Pathways associated with anti-CTNNA3 antibody

Products by Pathway	Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Bacterial Invasion Of Epithelial Cells Pathway antibodies	Bacterial Invasion Of Epithelial Cells Pathway Diagram
Bacterial Invasion Of Epithelial Cells Pathway antibodies	Bacterial Invasion Of Epithelial Cells Pathway Diagram
Endometrial Cancer Pathway antibodies	Endometrial Cancer Pathway Diagram
Endometrial Cancer Pathway antibodies	Endometrial Cancer Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram

Diseases associated with anti-CTNNA3 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>7 publications with CTNNA3 and Neoplasms
Asthma, Occupational Antibodies	>3 publications with CTNNA3 and Asthma, Occupational
Immune System Diseases Antibodies	>3 publications with CTNNA3 and Immune System Diseases
Asthma Antibodies	>3 publications with CTNNA3 and Asthma
Heart Defects, Congenital Antibodies	>2 publications with CTNNA3 and Heart Defects, Congenital
Autoimmune Diseases Antibodies	>1 publications with CTNNA3 and Autoimmune Diseases
Bone Diseases Antibodies	>1 publications with CTNNA3 and Bone Diseases
Lung Neoplasms Antibodies	>1 publications with CTNNA3 and Lung Neoplasms

Organs/Tissues associated with anti-CTNNA3 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with CTNNA3 and Brain
Heart Antibodies	>6 publications with CTNNA3 and Heart
Nerve Antibodies	>3 publications with CTNNA3 and Nerve
Embryonic Tissue Antibodies	>3 publications with CTNNA3 and Embryonic Tissue
Testis Antibodies	>3 publications with CTNNA3 and Testis