Cytokeratin 16 / Keratin K16 Antibody – Mouse Monoclonal

CytokeRatins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual cytokeRatin polypeptides are numbered 1 to 20. The various epithelia in the Human body usually express cytokeRatins which are not only characteristic of the type of epithelium, but also related to the degree of matuRation or differentiation within an epithelium. CytokeRatin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeRatin antibodies are not only of assistance in the differential identification of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Wetzels, R.H.W., Kuijpers H.J.H., Lane, E.B., Leigh, I.M., Troyanovsky, S.M., Holland, R., van Haelst, U.J.G.M., Ramaekers, F.C.S. (1991). Basal cell-specific and hyperprolifeRation-related keRatins in Human breast cancer. Am. J. Pathol. 138, 751-63. Porter, R.M., Lunny, D.P., Ogden, P.H., Morley, S.M., McLean, W.H., Evans, A., Harrison, D.L., Rugg, E.L., Lane, E.B. (2000). K15 expression implies lateral differentiation within stRatified epithelial basal cells. Lab Invest. 80, 1701-10. Ahenkorah, A., Hottor, B., Byrne, S., Bosio, P. and Ockleford, C.D. (2008). Immunofluorescence confocal laser scanning microscopy and immuno-electron microscopic identifiCation of keRatins in Human materno-foetal interaction zone. J. Cell. Mol. Med. 13, 735-48. van Lingen, R.G., Poll, M.K.P., Seyger, M.M.B., de Jong, E.M.G.J., van de Kerkhof, P.C.M., van Erp, P.E.J. (2008). Distribution of peptidyl-peptidase IV on keRatinocytes in the margin zone of a psoriatic lesion: a comparison with hyperprolifeRation and aberrant differentiation markers. Arch Dermatol Res 300, 561-67. Poschmann, G., Sitek, B., Sipos, B., Ulrich, A., Wiese, S., Stephan, C., Warscheid, B., Klöppel, G., Vander Borght, A., Ramaekers, F.C.S., Meyer, E. and Stühler, K. (2009). IdentifiCation of proteomic differences between squamous cell carcinoma of the lung and bronchial epithelium. Molecular & Cellular proteomics 8, 1105-16.

Small volumes of anti-CytokeRatin 16 / KeRatin K16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570081 is an antibody targeting CytokeRatin 16 / KeRatin K16. Also known as Mouse anti CytokeRatin 16 / KeRatin K16. Reactive in Human. Host: Mouse.