Mouse Anti-CHGA Monoclonal Antibody – Cat# MBS570093

Chromogranin A (CHGA) Antibody – Mouse Monoclonal

Name: CHGA Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS570093
Price: 540 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS570093

Neurons and neuroendocrine cells contain membrane-delimited pools of peptide hormones, biogenic amines, and neurotransmitters with a characteristic electron-dense appearance. These vesicles, which are present throughout the neuroendocrine system and in a… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Chromogranin A (CHGA), Monoclonal Antibody

Full Product Name

Mouse anti Chromogranin A

Product Gene Name

anti-CHGA antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

LK2H10

Host

Mouse

Species Reactivity

Human

Form/Format

Each vial contains 1 ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide.

Specificity

LK2H10 reacts with the soluble secretory protein Chromogranin A.

Preparation and Storage

Store undiluted antibody at 2-8 degree C (until expiry date). For prolonged storage: store aliquots at -20 degree C.

Molecular Weight

50,688 Da

Chromosome Location

Chromosome: 14; NC_000014.8 (93389445..93401638). Location: 14q32

OMIM

118910

3D Structure

ModBase 3D Structure for P10645

Source Note

LK2H10 is a Mouse monoclonal IgG1 antibody derived by fusion of NS-1 Mouse myeloma cells with spleen cells from a BABL/c Mouse immunized with an immunogen that has been isolated from Human pheochromocytoma.

Applications Tested/Suitable for anti-CHGA antibody

Immunohistochemistry (IHC) (frozen), Immunohistochemistry (IHC) (paraffin)

Application Notes for anti-CHGA antibody

LK2H10 is useful for immunohistochemistry on paraffin embedded and frozen tissues. Optimal antibody dilution should be determined by titRation; recommended dilution 1:10 when applied in the Indirect immunofluorescence method. With the ABC method the dilution can be 5-10x higher. Dilute immediately before use with PBS or TRIS-HCl pH 7,0.

Product References and Citations for anti-CHGA antibody

Taupenot, L., Harper, K.L., O'Connor, D.T. (2003). The chromogranin-secretogranin family. N Engl J Med 348, 1134-49. Lloyd, R.V. and Wilson, B.S. (1983). Specific endocrine tissue marker defined by a monoclonal antibody. Science 222, 628-30. Wilson, B.S. and Lloyd, R.V. (1984). Detection of chromagranin in neuroendocrine cells with a monoclonal antibody. Am J Pathol 115, 458-68.

Other Notes

Small volumes of anti-CHGA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHGA purchase

MBS570093 is an antibody targeting CHGA. Also known as Mouse anti Chromogranin A. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CHGA. It may not necessarily be applicable to this product.

NCBI GI #

4502805

NCBI GeneID

1113

NCBI Accession #

NP_001266.1

UniProt Primary Accession #

P10645

UniProt Secondary Accession #

Q53FA8; Q6NR84; Q96E84; Q96GL7; Q9BQB5; B2R9E9

UniProt Related Accession #

P10645; Q86T07

GenBank Nucleotide #

NM_001275.3

NCBI Official Full Name

chromogranin-A preproprotein

NCBI Official Synonym Full Names

chromogranin A (parathyroid secretory protein 1)

NCBI Official Symbol

CHGA

NCBI Official Synonym Symbols

CGA

UniProt Protein Name

Chromogranin-A

UniProt Synonym Protein Names

Pituitary secretory protein I; SP-ICleaved into the following 13 chains:Vasostatin-1; Alternative name(s):; Vasostatin IVasostatin-2; Alternative name(s):; Vasostatin II

Protein Family

Chromogranin

UniProt Gene Name

CHGA

UniProt Entry Name

CMGA_HUMAN

NCBI Protein Information

chromogranin-A; SP-I; pituitary secretory protein I; parathyroid secretory protein 1; betagranin (N-terminal fragment of chromogranin A)

NCBI Summary for CHGA

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq]

UniProt Comments for CHGA

CHGA: a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells and is a precursor to multiple biologically active peptides including vasostatin, pancreastatin, and chromostatin. Binds calcium with a low-affinity. Vasostatin negatively regulates angiogenesis and has antibacterial activity against some Gram-positive bacteria. Pancreastatin inhibits glucose induced insulin release from the pancreas. Chromostatin inhibits catecholamine release from chromaffin cells.

Protein type: Secreted, signal peptide; Cell adhesion; Secreted; Vesicle

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: perinuclear region of cytoplasm; extracellular region; secretory granule

Biological Process: regulation of blood pressure

Research Articles on CHGA

1. These findings indicate that CGA is tonically released by the adrenal gland but do not support the usefulness of using CGA instead of cortisol for assessing the selectivity of blood sampling

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CHGA antibody

Reference Product	PubMed Publications
SCG3 antibody	>1 publications with CHGA and SCG3

Diseases associated with anti-CHGA antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>284 publications with CHGA and Neoplasms
Carcinoma Antibodies	>154 publications with CHGA and Carcinoma
Neuroectodermal Tumors Antibodies	>139 publications with CHGA and Neuroectodermal Tumors
Adenocarcinoma Antibodies	>106 publications with CHGA and Adenocarcinoma
Pheochromocytoma Antibodies	>61 publications with CHGA and Pheochromocytoma
Pancreatic Neoplasms Antibodies	>55 publications with CHGA and Pancreatic Neoplasms
Hypertension Antibodies	>50 publications with CHGA and Hypertension
Prostatic Neoplasms Antibodies	>49 publications with CHGA and Prostatic Neoplasms
Lung Neoplasms Antibodies	>42 publications with CHGA and Lung Neoplasms
Respiratory Tract Diseases Antibodies	>39 publications with CHGA and Respiratory Tract Diseases

Organs/Tissues associated with anti-CHGA antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>101 publications with CHGA and Nerve
Adrenal Gland Antibodies	>77 publications with CHGA and Adrenal Gland
Prostate Antibodies	>51 publications with CHGA and Prostate
Stomach Antibodies	>46 publications with CHGA and Stomach
Lung Antibodies	>45 publications with CHGA and Lung
Brain Antibodies	>43 publications with CHGA and Brain
Thyroid Antibodies	>42 publications with CHGA and Thyroid
Pancreas Antibodies	>32 publications with CHGA and Pancreas
Parathyroid Antibodies	>28 publications with CHGA and Parathyroid
Kidney Antibodies	>23 publications with CHGA and Kidney