NCAM Antibody – Mouse Monoclonal

NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be geneRated by alternative splicing and by posttranslational modifiCations, such as sialylation. During sialylation, polysialic acid (PSA) carbohydRates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.

Broers, J. L., Mijnheere, E. P., Rot, M. K., Schaart, G., Sijlmans, A., Boerman, O. C., and Ramaekers, F. C. (1991). Novel antigens characteristic of neuroendocrine malignancies, Cancer 67, 619-33. Mijnheere, E. P., Boerman, O. C., Broers, J. L., Klein Rot, M., Vooijs, G. P., and Ramaekers, F. C. (1991). Immunotargeting of Human small cell lung cancer xenografts in athymic mice using a monoclonal antibody (RNL-1) anti a neuroendocrine- related antigen, Br J Cancer Suppl 14, 78-81. Boerman, O. C., Mijnheere, E. P., Broers, J. L., Vooijs, G. P., and Ramaekers, F. C. (1991). Biodistribution of a monoclonal antibody (RNL-1) anti the neural cell adhesion molecule (NCAM) in athymic mice bearing Human small-cell lung-cancer xenografts, Int J Cancer 48, 457-62. Mijnheere, E. P., Boerman, O. C., Poels, L. G., Slobbe, R. L., van Eys, G. J. J. M., and Ramaekers, F. C. S. (1996). Pharmacokinetics, biodistribution and dosimetry of anti-NCAM monoclonal antibody RNL-1 and its fragments in experimental lung cancer, Journal of Experimental and Clinical Cancer Research 15, 11-18. Hens, J., Nuydens, R., Geerts, H., Senden, N. H., Van de Ven, W. J., Roebroek, A. J., van de Velde, H. J., Ramaekers, F. C., and Broers, J. L. (1998). Neuronal differentiation is accompanied by NSP-C expression, Cell Tissue Res 292, 229-37.

Small volumes of anti-NCAM / CD56 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570106 is an antibody targeting NCAM / CD56. Also known as Mouse anti NCAM / CD56. Reactive in Human, Mouse. Host: Mouse.