Cytokeratin 10 / Keratin K10 Antibody – Mouse Monoclonal

CytokeRatins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in Human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual Human cytokeRatins are numbered 1 to 20. The various epithelia in the Human body usually express cytokeRatins which are not only characteristic of the type of epithelium, but also related to the degree of matuRation or differentiation within an epithelium. CytokeRatin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeRatin antibodies are not only of assistance in the differential identification of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Ramaekers, F. C., Puts, J. J., Moesker, O., Kant, A., Huysmans, A., Haag, D., Jap, P. H., Herman, C. J., and Vooijs, G. P. (1983). Antibodies to intermediate filament proteins in the immunohistochemical identifiCation of Human tumours: an overview, Histochem J 15, 691-713. Puts, J. J., Moesker, O., Kenemans, P., Vooijs, G. P., and Ramaekers, F. C. (1985). Expression of cytokeRatins in early neoplastic epithelial lesions of the uterine cervix, Int J Gynecol Pathol 4, 300-13. Broers, J. L., Carney, D. N., Klein Rot, M., Schaart, G., Lane, E. B., Vooijs, G. P., and Ramaekers, F. C. (1986). Intermediate filament proteins in classic and variant types of small cell lung carcinoma cell lines: a biochemical and immunochemical analysis using a panel of monoclonal and polyclonal antibodies, J Cell Sci 83, 37-60. Ramaekers, F., Huysmans, A., Schaart, G., Moesker, O., and Vooijs, P. (1987). Tissue distribution of keRatin 7 as monitored by a monoclonal antibody, Exp Cell Res 170, 235-49. Van Muijen, G. N., Warnaar, S. O., and Ponec, M. (1987). Differentiation-related changes of cytokeRatin expression in cultured keRatinocytes and in fetal, newborn, and adult epidermis, Exp Cell Res 171, 331-45. Bijman, J.T., Wagener, D.J.T., van Rennes, H., Wessels, J.M.C., Ramaekers, F.C.S. and van den Broek, P. (1987). Modulation of placental alkaline phosphatase activity and cytokeRatins in Human HN-1 cells by butyRate, retinoic acid, Catecholamines and histamine, Br. J. Cancer 56, 127-32. Van Erp, P.E.J., Rijzewijk, J.J., Boezeman, J.B.M., Leenders, J., de Mare, S., Schalkwijk, J., van de Kerkhof, P.C.M., Ramaekers, F.C.S. and Bauer, F.W. (1989). Flow Cytometric analysis of epidermal subpopulations from normal and psoriatic skin using monoclonal antibodies anti intermediate filaments, Am J Pathol 135, 865-70. Ramaekers, F., van Niekerk, C., Poels, L., Schaafsma, E., Huijsmans, A., Robben, H., Schaart, G., and Vooijs, P. (1990). Use of monoclonal antibodies to keRatin 7 in the differential diagnosis of adenocarcinomas, Am J Pathol 136, 641-55. Schaafsma, H. E., Ramaekers, F. C., van Muijen, G. N., Lane, E. B., Leigh, I. M., Robben, H., Huijsmans, A., Ooms, E. C., and Ruiter, D. J. (1990). Distribution of cytokeRatin polypeptides in Human transitional cell carcinomas, with special emphasis on changing expression patterns during tumor progression, Am J Pathol 136, 329-43. Smedts, F., Ramaekers, F., Robben, H., Pruszczynski, M., van Muijen, G., Lane, B., Leigh, I., and Vooijs, P. (1990). Changing patterns of keRatin expression during progression of cervical intraepithelial neoplasia, Am J Pathol 136, 657-68. Franssen, M.E.J., Boezeman, J.B.M., van de Kerkhof, P.C.M. and van Erp, P.E.J. (2003). Monitoring hyperprolifeRative disorders in Human skin: flow cytometry of changing cytokeRatin expression, Cytometry Part B (Clinical Cytometry) 57B, 32-39.

Small volumes of anti-CytokeRatin 10 / KeRatin K10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570114 is an antibody targeting CytokeRatin 10 / KeRatin K10. Also known as Mouse anti CytokeRatin 10 / KeRatin K10. Reactive in Canine, Human, Mouse, Rat, Swine, Zebrafish. Host: Mouse.