Neurofilament 70 Kd Antibody – Mouse Monoclonal

Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. The neurofilament (NF) triplet proteins (70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are normally restricted to neurons. The 70 kDa NF-protein can self-assemble into a filamentous structure, whereas the 160 kDa and 200 kDa NF-proteins require the presence of the 70 kDa NF-protein to co-assemble. All three NF proteins can be detected by immunohistochemical methods at day 9 or 10 after gestation in the Mouse embryo. Although IFPs of the neurofilament type are normally restricted to neurons, there are reports on their expression in non-neuronal cells as well. For example, in heart conduction myocytes NF proteins are expressed together with desmin. In tumorpathology ganglioneuroblastomas and some of the other neuroblastomas are strongly positive with the neurofilament antisera. Also, some neuro-endocrine malignancies may show NF positivity. In cell cultures of neural tissues the neurofilament antibodies can monitor in vitro differentiation.

Kluck, P., van Muijen, G. N., van der Kamp, A. W., Tibboel, D., van Hoorn, W. A., Warnaar, S. O., and Molenaar, J. C. (1984). Hirschsprung's disease studied with monoclonal antineurofilament antibodies on tissue sections, Lancet 1, 652-4. van Muijen, G. N., Ruiter, D. J., van Leeuwen, C., Prins, F. A., Rietsema, K., and Warnaar, S. O. (1984). CytokeRatin and neurofilament in lung carcinomas, Am J Pathol 116, 363-9. Breckenridge, L. J., Sommer, I. U., and Blackshaw, S. E. (1997). Developmentally regulated markers in the postnatal cervical spinal cord of the opossum Monodelphis domestica, Brain Res Dev Brain Res 103, 47-57.

Small volumes of anti-Neurofilament 70 kD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570140 is an antibody targeting Neurofilament 70 kD. Also known as Mouse anti Neurofilament 70 kD. Reactive in Human. Host: Mouse.