Nestin (NES) Antibody – Mouse Monoclonal

Nestin is a Class IV intermediate filament protein abundantly produced in the developing central nervous system (CNS) and in early embryonic neuroepithelial stem cells. This cytoskeletal protein has been widely used as a predominant marker for stem/progenitor cells, glioma cells, and tumor endothelial cells. Also, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumors. These highly specific antibodies to Human nestin can aid in characterizing progenitor cells differentiating into distinct lineages, in enhancing the therapeutic potential of Human neural stem/progenitor cells in the treatment of CNS diseases or injury, and in identifying neuroepithelial tumor cells.

Messam, C., Hou, J. and Major, E.O. (2000). Co-expression of nestin in neural and glial cells in the developing Human CNS defined by a Human specific anti-nestin antibody. Exp Neurol. 161, 585-96. Messam, C., Hou, J., Berman, J.W., and Major, E.O. (2002) Analysis of the temporal expression of nestin in Human fetal brain derived neuronal and glial progenitor cells. Brain Res Dev Brain Res. 134, 87-92. Hou, Y.Y., et al. (2006). Schwannoma of the gastrointestinal tract: a clinicopathological, immunohistochemical and ultrastructural study of 33 cases. Histopathology 48, 536-45. Mokry, J., Pudil, R., Ehrmann, J., Cizkova, D., Osterreicher, J., Filip, S. and Kolar, Z. (2008). Re-expression of nestin in the myocardium of postinfarcted patients. Virchows Arch 453, 33-41. Corsino, P.E., et al. (2008). Mammary tumors initiated by constitutive Cdk2 activation contain an invasive basal-like component. Neoplasia 10, 1240-52. Murphy, A.J., Viero, S., Ho, M. and Thorner, P.S. (2009). Diagnostic utility of nestin expression in pediatric tumors in the region of the kidney. Appl Immunohistochem Mol Morphol. 17, 517-23. Sellheyer, K. and Krahl, D. (2010). Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: a study on embryonic and adult Human skin. J. Am. Acad. Dermatol. 63, 93-113. Elamin, M.H., et al. (2010). Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells. Mol. Carcinog. 49, 302-14. Popescu, L.M., et al. (2010). Telocytes in Human epicardium. J. Cell. Mol. Med. 14, 2085-93. Sellheyer, K. and Krahl, D. (2011). Does the peritumoral stroma of basal cell carcinoma recapitulate the follicular connective tissue sheath? J. Cutan. Pathol. 38, 551-9.

Small volumes of anti-NES antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570163 is an antibody targeting NES. Also known as Mouse anti Nestin. Reactive in Human. Host: Mouse.