HLA Antibody – Mouse Monoclonal

HLA-DQ (DQ) is a cell surface receptor type protein found on antigen presenting cells. DQ is an αβ heterodimer of the MHC Class II type. The α and β chains are encoded by HLA-DQA1 and HLA-DQB1, respectively. These two loci are adjacent to each other on chromosome 6p21.3. Both the α-chain and β-chain vary greatly. A person often produces two α-chain and two β-chain variants and thus 4 DQ isoforms. The DQ loci are in close genetic linkage to HLA-DR but less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. DQ functions on antigen presenting cells, and is an antigen presenting molecule. Different DQ isoforms can bind to and present different antigens to T-cells. In this process T-cells are stimulated to grow and can signal B-cells to produce antibodies. DQ functions in recognizing and presenting foreign antigens (proteins derived from potential pathogens). But DQ is also involved in recognizing common self-antigens and presenting those antigens to the immune system in order to develop tolerance from a very young age. When tolerance to self proteins is lost, DQ may become involved in autoimmune disease. Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and diabetes mellitus type 1. DQ is one of several antigens involved in rejection of organ transplants. As a variable cell surface receptor on immune cells, these D antigens, originally HL-A4 antigens, are involved in graft versus host disease when lymphoid tissues are transplanted between people.

Spits H., G. Keizer, J. Borst, C. Terhorst, A. Hekman and J.E. de Vries. Characterization of monoclonal antibodies anti cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines. Hybridoma 1983, 4: 423-437. Spits H., J. Borst, M. Giphart, J. Coligan, C. Terhorst and J.E. de Vries. HLA-DC antigens can serve as recognition elements for Human cytotoxic T lymphocytes. Eur. J. Immunol. 1984, 14: 299. A.A. te Velde, J.P.G. Klomp, B.A. Yard, J.E. de Vries, C.G. Figdor. Modulation of phenotypic and functional properties of Human peripheral blood monocytes by IL-4. J. of Immunol. 1988, 140: 1548-1554.

Small volumes of anti-HLA DQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570226 is an antibody targeting HLA DQ. Also known as Mouse anti Human HLA DQ. Reactive in Human, Swine. Host: Mouse (Balb/c).