Neu-Oncogen (C-Erb B2) Antibody – Mouse Monoclonal

C-erbB-2 (erythroblastosis oncogene B), also known as HER2 (Human Epidermal Growth Factor Receptor 2), or Neu, CD340 and p185 is a protein that in Humans is encoded by the ERBB2 gene. AmplifiCation or overexpression of this gene has been shown to play an important role in the pathogenesis and progression of certain aggressive types of breast cancer, as well as many other epithelial malignancies and brain tumors. In recent years it has become an important biomarker and target of therapy for disease. ERBB2 is a known proto-oncogene loCated at the long arm of Human chromosome 17 (17q21-q22). The oncogene was found to code for EGFR. Gene cloning showed that HER2, Neu and ErbB-2 are all encoded by the same gene. The ErbB family is composed of plasma membrane-bound receptor tyrosine kinases, that contain an extracellular ligand binding domain, a transmembrane domain and an intracellular domain that can interact with a multitude of signaling molecules. HER2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways.

Van de Vijver, M.J., Peterse, J.L., Mooi, W.J., Wisman, P., Lomans, J., Dalesio, O. and Nusse, R. (1988). Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer.. N Engl J Med. 319, 1239-45. De Potter, C.R., Van Daele, S., Van de Vijver, M.J., Pauwels, C., Maertens, G., De Boever, J., Vandekerckhove, D. and Roels, H. (1989). The expression of the neu oncogene product in breast lesions and in normal fetal and adult Human tissues. Histopathology 15, 351-62. De Potter, C.R., Quatacker, J., Maertens, G., Van Daele, S., Pauwels, C., Verhofstede, C., Eechaute, W. and Roels, H. (1989). The subcellular localization of the neu protein in Human normal and neoplastic cells. Int J Cancer 44, 969-74. Van Leeuwen, F., Van de Vijver, M.J., Lomans, J., Van Deemter, L., Jenster, G., Akiyama, T., Yamamoto, T. and Nusse, R. (1990). Mutation of the Human neu protein facilitates down-modulation by monoclonal antibodies. Oncogene. 5, 497-503. Singleton, T.P., Niehans, G.A., Gu, F., Litz, C.E., Hagen, K., Qiu, Q., Kiang, D.T. and Strickler, J.G. (1992). Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry. Hum Pathol. 23, 1141-50. Schwechheimer, K., Läufle, R.M., Schmahl, W., Knödlseder, M., Fischer, H. and Höfler, H. (1994). Expression of neu/c-erbB-2 in Human brain tumors. Hum Pathol. 25, 772-80.

Small volumes of anti-Neu-Oncogen (C-erb B2) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570234 is an antibody targeting Neu-Oncogen (C-erb B2). Also known as Mouse anti Neu-Oncogen (C-erb B2). Reactive in Human, Monkey, Mouse, Rat. Host: Mouse.