Integrin Alpha 6a / Cd49f Antibody – Rat Monoclonal

Integrins, are transmembrane glycoproteins that belong to the family of adhesion molecules. They promote interactions between cells and their environment being both other cells and the extra cellular matrix. Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated subunits, being an alpha-subunit of 95 kDa that is conserved through the superfamily and a more variable beta subunit of 150-170 kDa. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. One of the integrin alpha subunits is the integrin alpha 6 (alpha6) subunit. Integrin alpha6 (CD49f) primarily associates with the integrin beta 1 (beta1) or beta 4 (beta4) subunit to form the alpha6beta1 or laminin receptor and the alpha6beta4 heterodimer. The GoH3 monoclonal antibody recognizes cell surface antigens on epithelial cells, endothelial cells and in a variety of tissues in both Human and Mouse, and reacts with glycoproteins Ic (alpha6 integrin, also known as CD49f) complexed with glycoprotein IIa (beta1) as the VLA-6 (very late activation antigen) or laminin receptor on Human and Mouse platelets, lymphocytes, epithelial cells and a variety of other cell types. In normal epithelial cells and (colon) carcinoma cells, peripheral nerves, and endothelia however, glycoprotein Ic (alpha6) is not associated with IIa, but with a group of proteins collectively named beta4. These beta4 proteins can occur in multiple forms on certain cell types. The tumor associated homologue of this protein is the TSP-180 antigen, expressed in lung carcinomas, melanomas, Human tissue carcinomas and carcinoma cell lines but not on Human melanomas and fibroblasts. VLA-6 is expressed on peripheral T cells or thymocytes, the GoH3 monoclonal antibody induces a comitogenic signal and inhibits platelet adhesion to laminin, one of the three major components of the subendothelial matrix.

Ticchioni, M., Deckert, M., Bernard, G., Calandra, D., Breittmeyer, J.P., Imbert, V., Peyron, J.F. and Bernard, A. (1995). Comitogenic effects of very late activation antigens on CD3-stimulated Human thymocytes. J Immunol 154, 1207-15. Sonnenberg, A., Janssen, H., Hogervorst, F., Calafat, J. and Hilgers, J. (1987). A complex of platelet glycoproteins Ic and IIa identified by a Rat monoclonal antibody. J Biol Chem 262, 10376-83. Hemler, M.E., Crouse, C., Takada, Y. and Sonnenberg, A. (1988). Multiple very late antigen (VLA) heterodimers on platelets. J Biol Chem 263, 7660-5.

Small volumes of anti-Integrin alpha 6A / CD49f antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570250 is an antibody targeting Integrin alpha 6A / CD49f. Also known as Rat anti Integrin alpha 6A / CD49f. Reactive in Human, Mouse. Host: Rat.