Mouse Anti-CD106 Monoclonal Antibody – Cat# MBS570328

CD106 Antibody – Mouse Monoclonal

Name: CD106 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS570328
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS570328

CD106 is a 110kDa type 1 transmembrane sialoglycoprotein, which is also known as vascular cell adhesion molecule 1 (VCAM-1). The CD106 protein is primarily expressed on activated vascular endothelium but has also been detected on dendritic cell types,… More details

$605 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD106, Monoclonal Antibody

Full Product Name

Mouse anti Human CD106

Product Gene Name

anti-CD106 antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

B-K9

Host

Mouse

Species Reactivity

Human

Form/Format

Each vial contains 100ul 1mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.

Specificity

The mouse monoclonal antibody B-K9 recognizes human CD106.

Preparation and Storage

Store at 4 degree C, or in small aliquots at -20 degree C.

Molecular Weight

74,346 Da

OMIM

192225

3D Structure

ModBase 3D Structure for P19320

Source Note

B-K9 is a mouse monoclonal IgG1 antibody derived by fusion of X63/Ag8.653 mouse myeloma cells with spleen cells from BALB/c mice immunized with activated human umbilical vein endothelial cells.

Product Categories/Family for anti-CD106 antibody

Immunology; Cell Adhesion

Applications Tested/Suitable for anti-CD106 antibody

Flow Cytometry (FC/FACS)

Application Notes for anti-CD106 antibody

The antibody produced by clone B-K9 can be used for CD106 cell identification, quantification and isolation by flow cytometry.

The antibody has also been reported for use in blocking studies. For this application, please request a sodium azide free antibody format.

Optimal antibody dilutions for the different applications should be determined by titration. The recommended range for flow cytometry is 1:100 - 1:200.

Product References and Citations for anti-CD106 antibody

1) Wagner BJ, Lob S, Lindau D, Horzer H, Guckel B, Klein G, Glatzle J, Rammensee HG, Brucher BL, Konigsrainer A. Simvastatin reduces tumor cell adhesion to human peritoneal mesothelial cells by decreased expression of VCAM-1 and B1 integrin. Int. J. Oncol. 2011;39(6):1593 - 1600.
2) Ticchioni M, Raimondi V, Lamy L, Wijdenes J, Lindberg FP, Brown EJ, Bernard A. Integrin-associated protein (CD47/IAP) contributes to T cell arrest on inflammatory vascular endothelium under flow. FASEB J. 2001; 15:341-350

Other Notes

Small volumes of anti-CD106 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD106 purchase

MBS570328 is an antibody targeting CD106. Also known as Mouse anti Human CD106. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD106. It may not necessarily be applicable to this product.

NCBI GI #

4507875

NCBI GeneID

7412

NCBI Accession #

NP_001069.1

UniProt Primary Accession #

P19320

UniProt Secondary Accession #

Q6NUP8; A8K6R7; B4DKS4; E9PDD1

UniProt Related Accession #

P19320

GenBank Nucleotide #

NM_001078.3

NCBI Official Full Name

vascular cell adhesion protein 1 isoform a

NCBI Official Synonym Full Names

vascular cell adhesion molecule 1

NCBI Official Symbol

VCAM1

NCBI Official Synonym Symbols

CD106; INCAM-100

UniProt Protein Name

Vascular cell adhesion protein 1

UniProt Synonym Protein Names

INCAM-100; CD_antigen: CD106

Protein Family

Vascular cell adhesion protein

UniProt Gene Name

VCAM1

UniProt Synonym Gene Names

L1CAM; V-CAM 1; VCAM-1

UniProt Entry Name

VCAM1_HUMAN

NCBI Protein Information

vascular cell adhesion protein 1; CD106 antigen

NCBI Summary for CD106

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

UniProt Comments for CD106

VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 1p32-p31

Cellular Component: Golgi apparatus; extracellular space; cell surface; microvillus; endoplasmic reticulum; early endosome; integral to membrane; apical part of cell; plasma membrane; podosome; sarcolemma; external side of plasma membrane; filopodium

Molecular Function: integrin binding; amine oxidase activity; cell adhesion molecule binding

Biological Process: response to nicotine; extracellular matrix organization and biogenesis; chronic inflammatory response; regulation of immune response; viral reproduction; cell-matrix adhesion; cytokine and chemokine mediated signaling pathway; heart development; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; response to ionizing radiation; amine metabolic process; cell adhesion; leukocyte tethering or rolling; acute inflammatory response; response to nutrient; aging

Research Articles on CD106

1. Data indicate neither serum vascular cell adhesion molecule-1 (VCAM-1) levels nor serum epithelial cell adhesion molecule (EpCAM) levels were identified to have a prognostic role on either progression-free survival (PFS) and overall survival (OS).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD106 antibody

Reference Product	PubMed Publications
CD44 antibody	>14 publications with CD106 and CD44
ITGA4 antibody	>10 publications with CD106 and ITGA4
ITGB2 antibody	>6 publications with CD106 and ITGB2
ITGB1 antibody	>3 publications with CD106 and ITGB1
VEGFA antibody	>3 publications with CD106 and VEGFA
SRC antibody	>2 publications with CD106 and SRC
ITGAD antibody	>1 publications with CD106 and ITGAD

Pathways associated with anti-CD106 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cellular Roles Of Anthrax Toxin Pathway antibodies	Cellular Roles Of Anthrax Toxin Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram
HTLV-I Infection Pathway antibodies	HTLV-I Infection Pathway Diagram

Diseases associated with anti-CD106 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>82 publications with CD106 and Inflammation
Cardiovascular Diseases Antibodies	>54 publications with CD106 and Cardiovascular Diseases
Necrosis Antibodies	>49 publications with CD106 and Necrosis
Atherosclerosis Antibodies	>39 publications with CD106 and Atherosclerosis
Kidney Diseases Antibodies	>13 publications with CD106 and Kidney Diseases
Hypertension Antibodies	>12 publications with CD106 and Hypertension
Heart Diseases Antibodies	>11 publications with CD106 and Heart Diseases
Myocardial Ischemia Antibodies	>9 publications with CD106 and Myocardial Ischemia
Anemia Antibodies	>8 publications with CD106 and Anemia
Myocardial Infarction Antibodies	>7 publications with CD106 and Myocardial Infarction

Organs/Tissues associated with anti-CD106 antibody

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>200 publications with CD106 and Vascular
Blood Antibodies	>121 publications with CD106 and Blood
Kidney Antibodies	>23 publications with CD106 and Kidney
Embryonic Tissue Antibodies	>21 publications with CD106 and Embryonic Tissue
Brain Antibodies	>19 publications with CD106 and Brain
Heart Antibodies	>17 publications with CD106 and Heart
Liver Antibodies	>14 publications with CD106 and Liver
Lung Antibodies	>13 publications with CD106 and Lung
Skin Antibodies	>8 publications with CD106 and Skin
Lymph Node Antibodies	>7 publications with CD106 and Lymph Node