EpCAM/CD326/EPG-2/SCLC-CD2 Antibody – Mouse Monoclonal

The epithelial cell adhesion molecule (EpCAM), also known as CD326, is a 40 kD glycoprotein that is expressed at the basolateral cell membrane of simple, pseudo-stratified and transitional epithelia of normal adult tissues. EpCAM is reported to function as a homotypic calcium-independent cell adhesion molecule but studies suggest that EpCAM is also involved in cellular processes such as cell signalling, migration, proliferation and differentiation.

In humans, EpCAM is overexpressed in a wide range of epithelial carcinomas including lung, colorectal, breast, prostate, head and neck, and hepatic carcinomas. The EpCAM molecule has, therefore, been widely used as a marker for human carcinomas and has been considered as a potential target for immunotherapy. EpCAM is also present on exosomes, microvesicles that are abundantly secreted by tumor cells, and antibodies to EpCAM are widely used for the isolation and identification of these cancer derived exosomes.

Apart from EpCAM's role in cancer syndromes, homozygous mutations in the EpCAM gene have been identified in patients suffering from congenital tufting enteropathy, a rare autosomal recessive form of intractable diarrhea of infancy.

In addition, EpCAM expression may be causally related to maintaining stem cells, and therefore will be a valuable target for future avenues to generate human induced pluripotent stem cells

In rats, EpCAM (also known as the Gz-1 antigen) is differentially expressed during embryogenesis, from the fertilized rat oocyte to all subsequently arising epithelial structures, suggesting a role for EpCAM in the proliferation and differentiation of embryonic stems cells.

1. Moore TJ, de Boer-Brouwer M, van Dissel-Emiliani FM. 2002. Purified gonocytes from the neonatal rat form foci of proliferating germ cells in vitro.
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2. Schiechl H, Dohr G.1987. Immunohistochemical studies of the distribution of a basolateral-membrane protein in intestinal epithelial cells (GZ1-Ag) in rats using monoclonal antibodies. Histochemistry. 87:491-8.

3. Tarmann T, Dohr G, Schiechl H, Barth S, Hartmann M. 1990. Immunohistochemical detection of an epithelial membrane protein in rat embryos at different stages of development. Acta Anat. 137:141-5.

4. Dohr G, Tarmann T, Schiechl H. 1987. Different antigen expression on Wolffian and Müllerian cells in rat embryos as detected by monoclonal antibodies. Anat Embryol. 176:239-42.

Small volumes of anti-EpCAM/CD326/EPG-2/SCLC-CD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS570344 is an antibody targeting EpCAM/CD326/EPG-2/SCLC-CD2. Also known as Mouse anti EpCAM/CD326/EPG-2/SCLC-CD2 epithelial antigen. Reactive in Rat. Does not react with human. Host: Mouse.