Factor VIII Related Antigen (VWD) Antibody – Goat Polyclonal

The defined antibody reactivity is restricted to VWF. In immunoelectrophoresis, bi-dimensional electrophoresis and radial immunodiffusion (Ouchterlony) against normal plasma, a single precipitin line is obtained which shows a reaction of identity with precipitated purified FVIII/VWF. No precipitation is obtained with plasma of type 1 congenital Von Willebrand’s disease. It is strongly recommended to perform the EID-assay with the special agarose (Agarose Nordic nr.4) Nordic High Resolution Buffer and High resolution-buffered Agarose, performance tested to assure reliable and reproducible results. The threshold of detection in this technique is about 0.15 mg per 100 ml. Haemophilia A and Von Willebrand’s disease (VWD) are known to be FVIII/VWF deficiencies. Immunologic determination of VWF antigen enables to discriminate between these two bleeding conditions. Haemophilia A patients lack FVIIIC but have a normal level of VWFag. In VWD, both FVIIIC and VWFag are reduced. Active and inactive FVIII/VWF, its breakdown products and inactivated FVIII/VWF-inhibitor complexes all express antigen determinants of VWFag and may be recognized by polyclonal antisera. Determination f plasma VWFag levels in addition to the level of FVIIIC can contribute also to the detection of the carrier state in haemophilia A. While the level of VWFag is normal or even elevated, the average concentration of FVIIIC of carriers is about half of normal. Various types and subtypes of congenital VWD have been described. Cases of acquired VWD have been reported in association with several clinical diseases including autoimmune disease, systemic lupus erythematosus, benign monoclonal gammapathy and Waldenström’s macroglobulinemia.

Small volumes of anti-Factor VIII related antigen (VWD) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS573169 is an antibody targeting Factor VIII related antigen (VWD). Also known as Goat anti human Factor VIII related antigen (VWD). Host: Goat.