Choline Kinase (CHKA) Antibody – Rabbit Polyclonal

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CHKA: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. Belongs to the choline/ethanolamine kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.1.82; Kinase, other; EC 2.7.1.32; Lipid Metabolism - glycerophospholipid

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: cytosol

Molecular Function: choline binding; signal transducer activity; protein homodimerization activity; cholinesterase activity; drug binding; choline kinase activity; ethanolamine kinase activity; ATP binding

Biological Process: choline metabolic process; CDP-choline pathway; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphatidylcholine biosynthetic process; lipid metabolic process; signal transduction; lipid transport; phosphorylation